A stereospecific ruthenium-catalyzed allylic alkylation

被引：0

作者：

Trost, BM ^{[1
]}

Fraisse, PL ^{[1
]}

Ball, ZT ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 06期

关键词：

alkylation; allylic compounds; chirality transfer; homogeneous catalysis; regioselectivity; ruthenium;

D O I：

10.1002/1521-3773(20020315)41:6<1059::AID-ANIE1059>3.0.CO;2-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Good regioselectivity and chirality transfer for aryl-substituted allyl units is achieved in allylic alkylations with a wide range of nucleophiles by using the highly active ruthenium catalyst 1. This method provides a route to antidepressants such as (-)-fluoxetine from (S)-ephedrine (see scheme; Cp* = η5-C5Me5, TBAT = tetrabutylammonium triphenyldifluorosilicate).

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页码：1059 / +

页数：4

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