Addison's disease as a rare cause of chronically elevated liver enzymes

被引:12
作者
Gurakuqi, GC
Stadlbauer, V
Stepan, V
Warnkross, H
Trauner, M
机构
[1] Med Univ Graz, Klin Abt Gastroenterol & Hepatol, Med Univ Klin, A-8036 Graz, Austria
[2] Med Univ Graz, Klin Abt Endocrinol, Med Univ Klin, A-8036 Graz, Austria
来源
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2006年 / 44卷 / 02期
关键词
liver; Addison's disease; adrenocortical insufficiency; elevated liver enzymes;
D O I
10.1055/s-2005-858976
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Common causes of chronically elevated serum liver enzymes include fatty liver disease, chronic viral hepatitis, autoimmune hepatitis, or hereditary metabolic disorders. Adrenocortical insufficiency can also cause elevated liver enzymes. Since 1990 only 11 cases have been reported. We here report a 52-year-old man with elevated liver enzymes (1.5 x upper limit of normal) over the past 10 years. Furthermore, hyponatremia and hyperkalemia were noted. He complained of fatigue and low blood pressure over the past few years. At physical examination a dark complexion was noted. After ruling out chronic viral hepatitis, autoimmune disease, metabolic or hereditary disorders, rare causes of elevated liver enzymes were considered. The endocrinological work-up revealed Addison's disease as cause of serum electrolyte disturbance and elevated liver enzymes. The patient was successfully treated with hydrocortisol and fludrocortisol. After one week, liver enzymes, serum electrolytes and arterial blood pressure had normalized. In conclusion, for patients with constantly elevated liver enzymes also rare, extrahepatic diseases have to be considered. Addison's disease is a rare but fully reversible cause for elevated liver enzymes.
引用
收藏
页码:179 / 183
页数:5
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