Self-guided reconstruction for time-domain fluorescence molecular lifetime tomography

被引:4
作者
Cai, Chuangjian [1 ]
Cai, Wenjuan [1 ]
Cheng, Jiaju [1 ]
Yang, Yuxuan [1 ]
Luo, Jianwen [1 ,2 ]
机构
[1] Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Ctr Biomed Imaging Res, Beijing 100084, Peoples R China
基金
中国国家自然科学基金;
关键词
fluorescence molecular lifetime tomography; time domain; L1; regularization; self-guided; DIFFUSE OPTICAL TOMOGRAPHY; REGULARIZATION; FLUOROPHORES; ALGORITHM; PHANTOM; TISSUE; MOUSE;
D O I
10.1117/1.JBO.21.12.126012
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Fluorescence probes have distinct yields and lifetimes when located in different environments, which makes the reconstruction of fluorescence molecular lifetime tomography (FMLT) challenging. To enhance the reconstruction performance of time-domain (TD) FMLT with heterogeneous targets, a self-guided L-1 regularization projected steepest descent (SGL1PSD) algorithm is proposed. Different from other algorithms performed in time domain, SGL1PSD introduces a time-resolved strategy into fluorescence yield reconstruction. The algorithm consists of four steps. Step 1 reconstructs the initial yield map with full time gate strategy; steps 2-4 reconstruct the inverse lifetime map, the yield map, and the inverse lifetime map again with time-resolved strategy, respectively. The reconstruction result of each step is used as a priori for the reconstruction of the next step. Projected iterated Tikhonov regularization algorithm is adopted for the yield map reconstructions in steps 1 and 3 to provide a solution with iterative refinement and nonnegative constraint. The inverse lifetime map reconstructions in steps 2 and 4 are based on L-1 regularization projected steepest descent algorithm, which employ the L-1 regularization to reduce the ill-posedness of the high-dimensional nonlinear problem. Phantom experiments with heterogeneous targets at different edge-to-edge distances demonstrate that SGL1PSD can provide high resolution and quantification accuracy for TD FMLT. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
引用
收藏
页数:10
相关论文
共 28 条
[1]   Optical tomography in medical imaging [J].
Arridge, SR .
INVERSE PROBLEMS, 1999, 15 (02) :R41-R93
[2]   Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for In Vivo Imaging [J].
Berezin, Mikhail Y. ;
Akers, Walter J. ;
Guo, Kevin ;
Fischer, Georg M. ;
Daltrozzo, Ewald ;
Zumbusch, Andreas ;
Achilefu, Samuel .
BIOPHYSICAL JOURNAL, 2009, 97 (09) :L22-L24
[3]   Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of diffusive media [J].
Brambilla, Marco ;
Spinelli, Lorenzo ;
Pifferi, Antonio ;
Torricelli, Alessandro ;
Cubeddu, Rinaldo .
REVIEW OF SCIENTIFIC INSTRUMENTS, 2008, 79 (01)
[4]   Nonlinear greedy sparsity-constrained algorithm for direct reconstruction of fluorescence molecular lifetime tomography [J].
Cai, Chuangjian ;
Zhang, Lin ;
Cai, Wenjuan ;
Zhang, Dong ;
Lv, Yanlu ;
Luo, Jianwen .
BIOMEDICAL OPTICS EXPRESS, 2016, 7 (04) :1210-1226
[5]   Direct reconstruction method for time-domain fluorescence molecular lifetime tomography [J].
Cai, Chuangjian ;
Zhang, Lin ;
Zhang, Jiulou ;
Bai, Jing ;
Luo, Jianwen .
OPTICS LETTERS, 2015, 40 (17) :4038-4041
[6]   Feasibility of U-curve method to select the regularization parameter for fluorescence diffuse optical tomography in phantom and small animal studies [J].
Chamorro-Servent, Judit ;
Aguirre, Juan ;
Ripoll, Jorge ;
Jose Vaquero, Juan ;
Desco, Manuel .
OPTICS EXPRESS, 2011, 19 (12) :11490-11506
[7]   A self-normalized, full time-resolved method for fluorescence diffuse optical tomography [J].
Gao, Feng ;
Zhao, Huijuan ;
Zhang, Limin ;
Tanikawa, Yukari ;
Marjono, Andhi ;
Yamada, Yukio .
OPTICS EXPRESS, 2008, 16 (17) :13104-13121
[8]   Simultaneous fluorescence yield and lifetime tomography from time-resolved transmittances of small-animal-sized phantom [J].
Gao, Feng ;
Li, Jiao ;
Zhang, Limin ;
Poulet, Patrick ;
Zhao, Huijuan ;
Yamada, Yukio .
APPLIED OPTICS, 2010, 49 (16) :3163-3172
[9]   Tomographic lifetime imaging using combined early- and late-arriving photons [J].
Hou, Steven S. ;
Rice, William L. ;
Bacskai, Brian J. ;
Kumar, Anand T. N. .
OPTICS LETTERS, 2014, 39 (05) :1165-1168
[10]   Fluorescence lifetime properties of near-infrared cyanine dyes in relation to their structures [J].
Lee, Hyeran ;
Berezin, Mikhail Y. ;
Henary, Maged ;
Strekowski, Lucjan ;
Achilefu, Samuel .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2008, 200 (2-3) :438-444