Effects of a citrus based juice on biomarkers of oxidative stress in metabolic syndrome patients

被引：25

作者：

Bernabe, Juana ^{[1
]}

Mulero, Juana ^{[1
]}

Cerda, Begona ^{[1
]}

Garcia-Viguera, Cristina ^{[2
]}

Moreno, Diego A. ^{[2
]}

Parra, Soledad ^{[3
]}

Aviles, Francisco ^{[3
]}

Gil-Izquierdo, Angel ^{[2
]}

Abellan, Jose ^{[4
]}

Zafrilla, Pilar ^{[1
]}

机构：

[1] Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain

[2] CSIC, CEBAS, Phytochem Lab, Murcia 30100, Spain

[3] Hosp Univ Virgen de la Arrixaca, Murcia 30120, Spain

[4] Catholic Univ San Antonio, Chair Cardiovasc Risk, Murcia 30107, Spain

来源：

JOURNAL OF FUNCTIONAL FOODS | 2013年 / 5卷 / 03期

关键词：

Oxidative stress; Metabolic syndrome; Protein carbonyl content; 15-Isoprostane F-2; 8-OHdG; GSH/GSSH; ox-LDL; LOW-DENSITY-LIPOPROTEIN; ARONIA-MELANOCARPA; RISK-FACTORS; ANTIOXIDANT; DYSFUNCTION; LDL; MEN; SUPPLEMENTATION; ASSOCIATION; GLUTATHIONE;

D O I：

10.1016/j.jff.2013.02.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. The aim of this study was to analyze the effect of a citrus-based juice (juice citrus (95%) with 5% of aronia extract (Aronia melanocarpa)) on biomarkers of oxidative stress in patients with metabolic syndrome compared with healthy individuals. The study comprised 20 healthy subjects and 33 patients with metabolic syndrome. Eighteen patients consumed daily 300 mL of a citrus-based juice during 6 months and 15 patients consumed 300 mL of a placebo beverage. The control group consumed a citrus-based juice (CJ). Before, and at sixth months after consuming of a citrus-based juice the following parameters were determined: 15-isoprostane F-2, 8-hydroxydeoxyguanosine (8-OHdG), reduced and oxidized glutathione (GSH/GSSH), carbonyl groups and oxidized LDL (ox-LDL). After consuming CJ during 6 months the values of 8-OHdG, carbonyl groups and LDL-ox decreased in both analyzed groups and the values of GSH/GSSH increased. Significant differences were observed in both groups. Thus consumption of citrus-based juice improved the biomarkers of oxidative stress in metabolic syndrome patients. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1031 / 1038

页数：8