ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: A meta-analysis

被引:40
作者
Al-Rubeaan, Khalid [1 ]
Siddiqui, Khalid [1 ]
Saeb, Amr T. M. [1 ]
Nazir, Nyla [1 ]
Al-Naqeb, Dhekra [1 ]
Al-Qasim, Sara [1 ]
机构
[1] King Saud Univ, Strateg Ctr Diabet Res, Riyadh 11415, Saudi Arabia
关键词
Type; 2; diabetes; Arabs; Caucasians; Polymorphism; ANGIOTENSIN-CONVERTING ENZYME; GENOME-WIDE ASSOCIATION; TRANSCRIPTION-FACTOR-7-LIKE-2; TCF7L2; GENE; SENSITIVE POTASSIUM CHANNEL; KCNJ11 E23K POLYMORPHISM; METHYLENETETRAHYDROFOLATE REDUCTASE; PRO12ALA POLYMORPHISM; PPAR-GAMMA-2; INSULIN SENSITIVITY; RISK-FACTORS;
D O I
10.1016/j.gene.2013.02.017
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In this meta-analysis study, SNPs were investigated for their association with type 2 diabetes (T2D) in both Arab and Caucasian ethnicities. A total of 55 SNPs were analyzed, of which 11 fulfilled the selection criteria, and were used for analysis. It was found that TCF7L2 rs7903146 was significantly associated with a pooled OR of 1.155 (95%C.I. = 1.059-1.259), p < 0.0001 and I-2 = 78.30% among the Arab population, whereas among Caucasians, the pooled OR was 1.45 (95%C.I. = 1.386-1.516), p < 0.0001 and I-2 = 77.20%. KCNJ11 rs5219 was significantly associated in both the populations with a pooled OR of 1.176(1.092-1.268), p < 0.0001 and I-2 = 32.40% in Caucasians and a pooled OR of 1.28(1.111-1.475), p = 0.001 among Arabs. The ACE I/D polymorphism was found to be significantly associated with a pooled OR of 1.992 (95%C.I. = 1.774-2.236), p < 0.0001 and I-2 = 83.20% among the Arab population, whereas among Caucasians, the pooled OR was 1.078 (95%C.I. = 0.993-1.17), p = 0.073 and I-2 = 0%. Similarly, MTHFR C677T polymorphism was also found to be significantly associated among Arabs with a pooled OR of 1.924 (95%C.I. = 1.606-2.304), p < 0.0001 and I-2 = 27.20%, whereas among Caucasians, the pooled OR was 0.986 (95%C.I. = 0.868-1.122), p = 0.835 and I-2 = 0%. Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs. In conclusion, it seems from this study that both Arabs and Caucasians have different SNPs associated with T2D. Moreover, this study sheds light on the profound necessity for further investigations addressing the question of the genetic components of T2D in Arabs. (c) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:166 / 177
页数:12
相关论文
共 102 条
[1]  
Al-Nozha MM, 2004, SAUDI MED J, V25, P1603
[2]   Genetic Study of Saudi Diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes [J].
Alsmadi, Osama ;
Al-Rubeaan, Khalid ;
Wakil, Salma M. ;
Imtiaz, Faiqa ;
Mohamed, Gamal ;
Al-Saud, Haya ;
Abu Al-Saud, Nouran ;
Aldaghri, Nasser ;
Mohammad, Shahinaz ;
Meyer, Brian F. .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2008, 24 (02) :137-140
[3]   Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population [J].
Alsmadi, Osama ;
Al-Rubeaan, Khalid ;
Mohamed, Gamal ;
Alkayal, Fadi ;
Al-Saud, Haya ;
Abu Al-Saud, Nouran ;
Al-Daghri, Nasser ;
Mohammad, Shahinaz ;
Meyer, Brian F. .
BMC MEDICAL GENETICS, 2008, 9
[4]   The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].
Altshuler, D ;
Hirschhorn, JN ;
Klannemark, M ;
Lindgren, CM ;
Vohl, MC ;
Nemesh, J ;
Lane, CR ;
Schaffner, SF ;
Bolk, S ;
Brewer, C ;
Tuomi, T ;
Gaudet, D ;
Hudson, TJ ;
Daly, M ;
Groop, L ;
Lander, ES .
NATURE GENETICS, 2000, 26 (01) :76-80
[5]  
[Anonymous], 2010, International Journal of Diabetes Mellitus, DOI DOI 10.1016/J.IJDM.2009.12.009
[6]  
[Anonymous], EXP MOL MED
[7]   Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients [J].
Arfa, Imen ;
Abid, Abdelmajid ;
Nouira, Sonia ;
Elloumi-Zghal, Houda ;
Malouche, Dhafer ;
Mannai, Imen ;
Zorgati, Mohamed Majdi ;
Ben Alaya, Nissaf ;
Rebai, Ahmed ;
Zouari, Bechir ;
Ben Ammar, Slim ;
Ben Rayana, Mohamed Chiheb ;
Hmida, Slama ;
Blousa-Chabchoub, Samira ;
Abdelhak, Sonia .
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2008, 9 (01) :32-36
[8]   Lack of association between the Pro12Ala polymorphism of the PPAR-γ2 gene and type 2 diabetes mellitus in the Qatari consanguineous population [J].
Badii, Ramin ;
Bener, Abdulbari ;
Zirie, Mahmoud ;
Al-Rikabi, Ammar ;
Simsek, Mehmet ;
Al-Hamaq, Abdulla O. A. A. ;
Ghoussaini, Maya ;
Froguel, Philippe ;
Wareham, Nick J. .
ACTA DIABETOLOGICA, 2008, 45 (01) :15-21
[9]   Association of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene with type 2 diabetes in two ethnic groups of Jerba Island in Tunisia [J].
Baroudi, Thouraya ;
Bouhaha, Rym ;
Moran-Moguel, Chrystine ;
Sanchez-Corona, Jose ;
Maiz, Hedi Ben ;
Abid, Hafaoua Kammoun ;
Benammar-Elgaaied, Amel .
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2009, 10 (01) :35-40
[10]   Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations [J].
Beamer, BA ;
Yen, CJ ;
Andersen, BE ;
Muller, D ;
Elahi, D ;
Cheskin, LJ ;
Andres, R ;
Roth, J ;
Shuldiner, AR .
DIABETES, 1998, 47 (11) :1806-1808