Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report

被引：5

作者：

Bassi, Roberto ^{[1
,2
,3
]}

Vergani, Andrea ^{[1
]}

D'Addio, Francesca ^{[1
,3
]}

Ben Nasr, Moufida ^{[1
]}

Mocci, Alessio ^{[1
,4
]}

Rastaldi, Maria Pia ^{[5
,6
]}

Ichimura, Takaharu ^{[7
]}

Bonventre, Joseph Vincent ^{[7
]}

Fiorina, Paolo ^{[1
,3
,7
]}

机构：

[1] Harvard Univ, Sch Med, Div Nephrol, Boston Childrens Hosp, Boston, MA 02210 USA

[2] Univ Salento, DiSTeBA, Lecce, Italy

[3] Ist Sci San Raffaele, Med, I-20132 Milan, Italy

[4] ASL, Dept Accid & Emergency, Bologna, Italy

[5] Fdn IRCCS Osped Maggiore Policlin, Renal Res Lab, Milan, Italy

[6] Fdn Amico Ric Malattie Renali, Milan, Italy

[7] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

来源：

SPRINGERPLUS | 2014年 / 3卷

关键词：

Ischemia/reperfusion; Kidney disease; Kidney transplantation; Radical oxygen species; Inflammation; ACUTE KIDNEY INJURY; ISCHEMIA-REPERFUSION INJURY; DISEASE; RATS;

D O I：

10.1186/2193-1801-3-158

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.

引用

页码：1 / 4

页数：4

共 15 条

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