AKT/mTOR Signal Cascade and Expression of PD-1, PD-L1, and PD-L2 in Gastric Cancer

被引：7

作者：

Spirina, L. V. ^{[1
,2
]}

Avgustinovich, A. V. ^{[1
]}

Afanas'ev, S. G. ^{[1
]}

Kondakova, I. V. ^{[1
]}

Volkov, M. Yu. ^{[1
]}

Dobrodeev, A. Yu. ^{[1
]}

Boronkina, A. I. ^{[2
]}

机构：

[1] Tomsk Natl Res Med Ctr, Canc Res Inst, Tomsk, Russia

[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 170卷 / 01期

关键词：

gastric cancer; AKT; mTOR signaling cascade; PD; PD-L1; PD-L2; PATHWAY; AKT;

D O I：

10.1007/s10517-020-05007-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with dissemination of gastric cancer. An increase in the mRNA level of all components of this cascade was demonstrated. The expression of mTOR and AKT decreased against the background of enhanced expression of PTEN phosphatase. The increase in the expression of PD-1 receptors and PD-L1 and PD-L2 ligands was most pronounced in patients with distant metastases.

引用

页码：75 / 78

页数：4

共 50 条

[31] Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer
Jorns, Julie M.
Sun, Yunguang
Kamaraju, Sailaja
Cheng, Yee Chung
Kong, Amanda
Yen, Tina
Patten, Caitlin R.
Cortina, Chandler S.
Chitambar, Christopher R.
Rui, Hallgeir
Chaudhary, Lubna N.
JOURNAL OF PERSONALIZED MEDICINE, 2024, 14 (05):
[32] Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer
Atsushi Shiozaki
Tomoyuki Fukami
Hiroki Shimizu
Toshiyuki Kosuga
Michihiro Kudou
Kenichi Takemoto
Keita Katsurahara
Keiji Nishibeppu
Takuma Ohashi
Tomohiro Arita
Hirotaka Konishi
Shuhei Komatsu
Takeshi Kubota
Hitoshi Fujiwara
Eigo Otsuji
Annals of Surgical Oncology, 2023, 30 : 8704 - 8716
[33] Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer
Shiozaki, Atsushi
Fukami, Tomoyuki
Shimizu, Hiroki
Kosuga, Toshiyuki
Kudou, Michihiro
Takemoto, Kenichi
Katsurahara, Keita
Nishibeppu, Keiji
Ohashi, Takuma
Arita, Tomohiro
Konishi, Hirotaka
Komatsu, Shuhei
Kubota, Takeshi
Fujiwara, Hitoshi
Otsuji, Eigo
ANNALS OF SURGICAL ONCOLOGY, 2023, 30 (13) : 8704 - 8716
[34] Robust Preanalytical Performance of Soluble PD-1, PD-L1 and PD-L2 Assessed by Sensitive ELISAs in Blood
Krueger, Kimberly
Mayer, Zsuzsanna
Kottmaier, Marc
Gerckens, Miriam
Boeck, Stefan
Luppa, Peter
Holdenrieder, Stefan
BIOMEDICINES, 2022, 10 (10)
[35] PD-1, CTLA4, PD-L1 and PD-L2 DNA methylation in papillary thyroid carcinoma
de Vos, Luka
Dietrich, Joern
Strieth, Sebastian
Bootz, Friedrich
Dietrich, Dimo
Franzen, Alina
IMMUNOTHERAPY, 2020, 12 (12) : 903 - 920
[36] Interferon-γ induced PD-L1 expression and soluble PD-L1 production in gastric cancer
Imai, Yushi
Chiba, Tetsuhiro
Kondo, Takayuki
Kanzaki, Hiroaki
Kanayama, Kengo
Ao, Junjie
Kojima, Ryuta
Kusakabe, Yuko
Nakamura, Masato
Saito, Tomoko
Nakagawa, Ryo
Suzuki, Eiichiro
Nakamoto, Shingo
Muroyama, Ryosuke
Tawada, Akinobu
Matsumura, Tomoaki
Nakagawa, Tomoo
Kato, Jun
Kotani, Ai
Matsubara, Hisahiro
Kato, Naoya
ONCOLOGY LETTERS, 2020, 20 (03) : 2161 - 2168
[37] PD-1 and PD-L1 inhibitors in oesophago-gastric cancers
Telli, Tugba Akin
Bregni, Giacomo
Camera, Silvia
Deleporte, Amelie
Hendlisz, Main
Sclafani, Francesco
CANCER LETTERS, 2020, 469 : 142 - 150
[38] PD-1 and PD-L1 antibodies for melanoma
Tsai, Katy K.
Zarzoso, Ines
Daud, Adil I.
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2014, 10 (11) : 3111 - 3116
[39] PD-1/PD-L1 inhibitors
Sunshine, Joel
Taube, Janis M.
CURRENT OPINION IN PHARMACOLOGY, 2015, 23 : 32 - 38
[40] PD-1/PD-L1 in disease
Kuol, Nyanbol
Stojanovska, Lily
Nurgali, Kulmira
Apostolopoulos, Vasso
IMMUNOTHERAPY, 2018, 10 (02) : 149 - 161

← 1 2 3 4 5 →