Koilocytosis: Correlations With High-Risk HPV and Its Comparison on Tissue Sections and Cytology, Urothelial Carcinoma

被引：17
|
作者：
Aggarwal, Seema [1 ,2 ]
Arora, Vinod K. [1 ,2 ]
Gupta, Sanjay [3 ]
Singh, Navjeevan [1 ,2 ]
Bhatia, Arati [1 ,2 ]
机构：
[1] Univ Coll Med Sci, Dept Pathol, Delhi 110095, India
[2] GTB Hosp, Delhi 110095, India
[3] Inst Cytopathol & Prevent Oncol, Dept Cytopathol, Noida, India
来源：
DIAGNOSTIC CYTOPATHOLOGY | 2009年 / 37卷 / 03期
关键词：
urothelial carcinoma; urine cytology; koilocytosis; HPV DNA; TRANSITIONAL-CELL CARCINOMA; HUMAN PAPILLOMAVIRUS INFECTION; POLYMERASE-CHAIN-REACTION; URINARY-BLADDER; BOVINE PAPILLOMAVIRUS; INDIAN WOMEN; CANCER; DNA; OVEREXPRESSION; HYBRIDIZATION;
D O I：
10.1002/dc.20978
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The aim of this study were (1) To correlate koilocytosis with high risk HPV(HrHPV) DNA in urinary bladder carcinoma and (2) To compare detection of koilocytosis on tissue sections and urine cytology. Biopsy and cytologic specimens from 33 patients of urinary bladder carcinoma were analyzed. HPV DNA was detected by PCR on biopsy specimens using consensus primers MY09 and MY11. Koilocytosis was assessed both on tissue sections and urine cytology. HrHPV DNA was found in 14 of 33 bladder carcinoma. Koilocytosis was seen tissue sections from 13 patients. Eleven of these were HrHPV DNA positive (positive predictive value 84.6%). Koilocytosis was seen in urine cytology in three patients. All three were positive for HrHPV DNA. To conclude koilocytosis is a good morphological marker for HrHPV DNA in the urothelium. Tissue sections are better than cytologic smears for detection of koilocytes. Diagn. Cytopathol, 2009; 37:174-177. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：174 / 177
页数：4
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