Koilocytosis: Correlations With High-Risk HPV and Its Comparison on Tissue Sections and Cytology, Urothelial Carcinoma

被引：17

作者：

Aggarwal, Seema ^{[1
,2
]}

Arora, Vinod K. ^{[1
,2
]}

Gupta, Sanjay ^{[3
]}

Singh, Navjeevan ^{[1
,2
]}

Bhatia, Arati ^{[1
,2
]}

机构：

[1] Univ Coll Med Sci, Dept Pathol, Delhi 110095, India

[2] GTB Hosp, Delhi 110095, India

[3] Inst Cytopathol & Prevent Oncol, Dept Cytopathol, Noida, India

来源：

DIAGNOSTIC CYTOPATHOLOGY | 2009年 / 37卷 / 03期

关键词：

urothelial carcinoma; urine cytology; koilocytosis; HPV DNA; TRANSITIONAL-CELL CARCINOMA; HUMAN PAPILLOMAVIRUS INFECTION; POLYMERASE-CHAIN-REACTION; URINARY-BLADDER; BOVINE PAPILLOMAVIRUS; INDIAN WOMEN; CANCER; DNA; OVEREXPRESSION; HYBRIDIZATION;

D O I：

10.1002/dc.20978

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The aim of this study were (1) To correlate koilocytosis with high risk HPV(HrHPV) DNA in urinary bladder carcinoma and (2) To compare detection of koilocytosis on tissue sections and urine cytology. Biopsy and cytologic specimens from 33 patients of urinary bladder carcinoma were analyzed. HPV DNA was detected by PCR on biopsy specimens using consensus primers MY09 and MY11. Koilocytosis was assessed both on tissue sections and urine cytology. HrHPV DNA was found in 14 of 33 bladder carcinoma. Koilocytosis was seen tissue sections from 13 patients. Eleven of these were HrHPV DNA positive (positive predictive value 84.6%). Koilocytosis was seen in urine cytology in three patients. All three were positive for HrHPV DNA. To conclude koilocytosis is a good morphological marker for HrHPV DNA in the urothelium. Tissue sections are better than cytologic smears for detection of koilocytes. Diagn. Cytopathol, 2009; 37:174-177. (C) 2009 Wiley-Liss, Inc.

引用

页码：174 / 177

页数：4

共 22 条

[1] Koilocytes in urinary cytology in a patient with kidney transplant [J].

Altamirano, Eugenia ;

Drut, Ricardo .

DIAGNOSTIC CYTOPATHOLOGY, 2008, 36 (05) :338-340

[2]

ANWAR K, 1992, CANCER-AM CANCER SOC, V70, P1967, DOI 10.1002/1097-0142(19921001)70:7<1967::AID-CNCR2820700726>3.0.CO

[3]

2-8

[4]

Bales C., 2006, KOSSS DIAGNOSTIC CYT, V5th

[5] Can we detect cervical human papillomavirus (HPV) infection by cytomorphology alone?: Diagnostic value of non-classic cytological signs of HPV effect in minimally abnormal Pap tests [J].

Bollmann, M ;

Bánkfalvi, A ;

Trosic, A ;

Speich, N ;

Schmitt, C ;

Bollmann, R .

CYTOPATHOLOGY, 2005, 16 (01) :13-21

[6] DEMONSTRATION OF PAPILLOMAVIRUS STRUCTURAL ANTIGEN IN HUMAN URINARY-BLADDER NEOPLASIA [J].

BRYANT, P ;

SKELLY, J ;

WILSON, D .

BRITISH JOURNAL OF UROLOGY, 1987, 60 (05) :405-409

[7] Bovine papillomavirus and cancer [J].

Campo, MS .

VETERINARY JOURNAL, 1997, 154 (03) :175-188

[8]

DAS BC, 1989, LANCET, V2, P1271

[9] Detection of human papillomavirus DNA in urinary bladder carcinoma by in situ hybridisation [J].

De Gaetani, C ;

Ferrari, G ;

Righi, E ;

Bettelli, S ;

Migaldi, M ;

Ferrari, P ;

Trentini, GP .

JOURNAL OF CLINICAL PATHOLOGY, 1999, 52 (02) :103-106

[10] The World Health Organization International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder [J].

Epstein, JI ;

Amin, MB ;

Reuter, VR ;

Mostofi, FK .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1998, 22 (12) :1435-1448

← 1 2 3 →