Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities

被引：14

作者：

Stock, Matthew L. ^{[1
]}

Fiedler, Kara J. ^{[1
]}

Acharya, Sreemoyee ^{[1
]}

Lange, Jennifer K. ^{[2
]}

Mlynarczyk, Gregory S. A. ^{[1
]}

Anderson, Stephen J. ^{[3
]}

McCormack, Garrett R. ^{[1
]}

Kanuri, Sri Harsha ^{[1
]}

Kondru, Naveen C. ^{[1
]}

Brewer, Matthew T. ^{[1
]}

Carlson, Steve A. ^{[1
]}

机构：

[1] Iowa State Univ, Coll Vet Med, Dept Biomed Sci, Ames, IA 50011 USA

[2] Iowa State Univ, Coll Human Sci, Dept Kinesiol, Ames, IA 50011 USA

[3] Iowa State Univ, Coll Liberal Arts & Sci, Dept Psychol, Ames, IA 50011 USA

来源：

NEUROPHARMACOLOGY | 2013年 / 73卷

关键词：

Antibacterial; Antifungal; Neuroprotection; BETA-LACTAM ANTIBIOTICS; NIGROSTRIATAL DOPAMINERGIC NEURODEGENERATION; AMYOTROPHIC-LATERAL-SCLEROSIS; ISCHEMIC BRAIN-INJURY; MOUSE MODEL; HUNTINGTONS-DISEASE; MAMMALIAN TARGET; GLUTAMATE TRANSPORTERS; MINOCYCLINE TREATMENT; MULTIPLE-SCLEROSIS;

D O I：

10.1016/j.neuropharm.2013.04.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, beta-lactam antibiotics are believed to increase the expression of glutamate transporter GLT1, potentially relieving the neurological excitotoxicity that characterizes disorders like amyotrophic lateral sclerosis. Minocyclihe has shown promise in reducing the severity of a number of neurological diseases, including multiple sclerosis, most likely by reducing apoptosis and the expression of inflammatory mediators in the brain. Rapamycin inhibits the activity of a serine/threonine protein kinase that has a role in the pathogenesis of numerous neurologic diseases. Herein we examine the unique neuroprotective aspects of these drugs originally developed as anti-infective agents. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：174 / 182

页数：9

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