Synthesis, spectral studies, in vitro antimicrobial activity and molecular docking studies of organotin(IV) complexes derived from tridentate Schiff base ligands

In this work, diorganotin complexes of Schiff base ligands having general formula R2SnL1-6, (where R = Bu, Me, Ph, and L1-6 are Schiff base ligands) were synthesized. Schiff base ligands were obtained by the condensation of methyl 3-amino-4-hydroxybenzoate and methyl 4-amino-3-hydroxybenzoate with salicylaldehyde derivatives in equimolar ratio. The structure of all synthesized compounds were confirmed by several spectroscopic techniques like elemental analysis, FT-IR, multi-nuclear (H-1, C-13, and Sn-119) NMR and mass spectrometery. From the spectroscopic data, it was found that the Schiff base ligands are coordinated to tin atom through -ONO donor atoms and tin atom exhibits pentacoordinated geometry in all complexes. The synthesized compounds were assessed for their in vitro antimicrobial potential against four bacterial and two fungal strains. Molecular docking studies of the most potent compound (9) was performed with enzyme 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of Escherichia coli and sterol 14-alpha demethylase of C. Albicans to study their interactions. [GRAPHICS] .