In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

被引：14
|
作者：
Gong, Xinghou [1 ,2 ,4 ]
Tang, Chak Yin [1 ]
Pan, Ling [2 ]
Hao, Zhonghua [3 ]
Tsui, Chi Pong [1 ]
Liu, Jianing [2 ]
机构：
[1] Hong Kong Polytech Univ, Dept Ind & Syst Engn, Hong Kong, Hong Kong, Peoples R China
[2] Hubei Univ Technol, Sch Mat Sci & Engn, Wuhan 430068, Peoples R China
[3] Wuhan Univ, Dept Phys, Wuhan 430072, Peoples R China
[4] Hubei Univ Technol, Hubei Prov Key Lab Green Mat Light Ind, Wuhan 430068, Peoples R China
来源：
COMPOSITES PART B-ENGINEERING | 2013年 / 55卷
基金：
中国国家自然科学基金;
关键词：
Polymer matrix composites (PMCs); Nano-structures; Optical properties/techniques; In vitro degradation; SEMICONDUCTOR QUANTUM DOTS; LEACHING METHOD; ACID) SCAFFOLD; VIVO; NANOCOMPOSITES; NANOPARTICLES; BIOCOMPATIBILITY; CYTOTOXICITY; NANOCRYSTALS; FABRICATION;
D O I：
10.1016/j.compositesb.2013.06.034
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this study, cadmium selenide/zinc sulfide (CdSe/ZnS) quantum dots (QDs) were introduced into poly(lactic acid) (PLA) for fabrication of photoluminescent PLA/QDs scaffolds. TEM images revealed that the QDs were uniformly dispersed in the PLA. Compressive modulus and thermal stability of the PLA/QDs scaffolds are higher than those of the unfilled PLA scaffold. Cytotoxicity test results confirmed the non-cytotoxicity of the PLA/QDs scaffolds. During the process of in vitro degradation, the degradation rate of the PLA was accelerated by the presence of the QDs, and the molecular weight distributions of the PLA/QDs scaffolds were much broader when compared with the unfilled PLA ones. During the first 84 weeks of the degradation process, the photoluminescence (PL) intensity of the PLA/QDs scaffolds decreased with almost the same degradation ratio. The results suggested that the CdSe/ZnS QDs have potential applications for monitoring in vivo degradation of tissue engineering scaffolds. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：234 / 239
页数：6
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