Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium

被引：26

作者：

Nogueira, MEI

Passoni, MH

Biso, FI

Longo, MD

Cardoso, CRP

dos Santos, LC

Varanda, EA

机构：

[1] Univ Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil

[2] Univ Estadual Paulista, UNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil

来源：

TOXICOLOGY IN VITRO | 2006年 / 20卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Salmonella typhimurium; antimutagenic activity; Melampodium divarication; triterpenes;

D O I：

10.1016/j.tiv.2005.08.012

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Melcanpodium divaricatian is a member of the Asteraccae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold (Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effect in the Sahnonella/microsome assay. The tested extract was not mutagenic in the strains TA100, TA98, TA97a and TA102 and decreased the mutagenicity of aflatoxin B1, benzo(a)pyrene and daunomycin. Chlorophyll and triterpenes were detected in the extract, and they might have contributed to the observed effect. Our data suggest that these medicinal plants possess cancer chemopreventive properties. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：361 / 366

页数：6

共 36 条

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