CD47: the next checkpoint target for cancer immunotherapy

被引：64

作者：

Feng, Ridong ^{[1
]}

Zhao, Hai ^{[1
]}

Xu, Jianguo ^{[1
]}

Shen, Chongyang ^{[2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Neurosurg, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Basic Med Sch, Chengdu 611137, Sichuan, Peoples R China

[3] Anhui Univ Chinese Med, Key Lab Xinan Med, Minist Educ, 103 Meishan Rd, Hefei 230038, Anhui, Peoples R China

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2020年 / 152卷

基金：

中国国家自然科学基金;

关键词：

CD47; TSP-1; innate checkpoint; immunotherapy; cancer therapy; SIGNAL-REGULATORY PROTEIN; INTEGRIN-ASSOCIATED PROTEIN; INNATE IMMUNE CHECKPOINT; INDEPENDENT CELL-DEATH; T-CELL; NEGATIVE REGULATION; ANTITUMOR-ACTIVITY; TUMOR-SUPPRESSOR; ADVERSE EVENTS; SIRP-ALPHA;

D O I：

10.1016/j.critrevonc.2020.103014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer immunotherapy using checkpoint blockade has brought about a paradigm shift in the treatment of advanced-stage cancers. Unfortunately, not all patients benefit from these therapies, paving the way for other immune checkpoints to be targeted. CD47, a 'marker-of-self protein that is overexpressed broadly across tumor types, is emerging as a novel potent macrophage immune checkpoint for cancer immunotherapy. Recently, CD47 blockade by Hu5F9-G4 has shown promise combined with Rituximab in non-Hodgkin's lymphoma. Here we review the complex structure and various physiological functions of CD47 and their implications in cancer biology. Further, this review considers future directions and challenges in advancing this promising target platform to widespread therapeutic use.

引用

页数：9

共 102 条

[1]

Adams S, 1998, J IMMUNOL, V161, P1853

[2] CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma [J].

Advani, Ranjana ;

Flinn, Ian ;

Popplewell, Leslie ;

Forero, Andres ;

Bartlett, Nancy L. ;

Ghosh, Nilanjan ;

Kline, Justin ;

Roschewski, Mark ;

LaCasce, Ann ;

Collins, Graham P. ;

Thu Tran ;

Lynn, Judith ;

Chen, James Y. ;

Volkmer, Jens-Peter ;

Agoram, Balaji ;

Huang, Jie ;

Majeti, Ravindra ;

Weissman, Irving L. ;

Takimoto, Chris H. ;

Chao, Mark P. ;

Smith, Sonali M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (18) :1711-1721

[3] Cell polarisation and the immunological synapse [J].

Angus, Karen L. ;

Griffiths, Gillian M. .

CURRENT OPINION IN CELL BIOLOGY, 2013, 25 (01) :85-91

[4]

[Anonymous], 2018, SCIENCE, DOI DOI 10.1126/SCIENCE.AAU1287

[5] SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47 [J].

Babic, I ;

Schallhorn, A ;

Lindberg, FP ;

Jirik, FR .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3652-3658

[6] The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target [J].

Barclay, A. Neil ;

van den Berg, Timo K. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32, 2014, 32 :25-50

[7] Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy [J].

Barkal, Amira A. ;

Weiskopf, Kipp ;

Kao, Kevin S. ;

Gordon, Sydney R. ;

Rosental, Benyamin ;

Yiu, Ying Y. ;

George, Benson M. ;

Markovic, Maxim ;

Ring, Nan G. ;

Tsai, Jonathan M. ;

McKenna, Kelly M. ;

Ho, Po Yi ;

Cheng, Robin Z. ;

Chen, James Y. ;

Barkal, Layla J. ;

Ring, Aaron M. ;

Weissman, Irving L. ;

Maute, Roy L. .

NATURE IMMUNOLOGY, 2018, 19 (01) :76-+

[8] Inhibition of profibrotic microRNA-21 affects platelets and their releasate [J].

Barwari, Temo ;

Eminaga, Seda ;

Mayr, Ursula ;

Lu, Ruifang ;

Armstrong, Paul C. ;

Chan, Melissa, V ;

Sahraei, Mahnaz ;

Fernandez-Fuertes, Marta ;

Moreau, Thomas ;

Barallobre-Barreiro, Javier ;

Lynch, Marc ;

Yin, Xiaoke ;

Schulte, Christian ;

Baig, Ferheen ;

Pechlaner, Raimund ;

Langley, Sarah R. ;

Zampetaki, Anna ;

Santer, Peter ;

Weger, Martin ;

Plasenzotti, Roberto ;

Schosserer, Markus ;

Grillari, Johannes ;

Kiechl, Stefan ;

Willeit, Johann ;

Shah, Ajay M. ;

Ghevaert, Cedric ;

Warner, Timothy D. ;

Fernandez-Hernando, Carlos ;

Suarez, Yajaira ;

Mayr, Manuel .

JCI INSIGHT, 2018, 3 (21)

[9] Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization [J].

Berkovits, Binyamin D. ;

Mayr, Christine .

NATURE, 2015, 522 (7556) :363-+

[10] Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline [J].

Brahmer, Julie R. ;

Lacchetti, Christina ;

Schneider, Bryan J. ;

Atkins, Michael B. ;

Brassil, Kelly J. ;

Caterino, Jeffrey M. ;

Chau, Ian ;

Ernstoff, Marc S. ;

Gardner, Jennifer M. ;

Ginex, Pamela ;

Hallmeyer, Sigrun ;

Chakrabarty, Jennifer Holter ;

Leighl, Natasha B. ;

Mammen, Jennifer S. ;

McDermott, David F. ;

Naing, Aung ;

Nastoupil, Loretta J. ;

Phillips, Tanyanika ;

Porter, Laura D. ;

Puzanov, Igor ;

Reichner, Cristina A. ;

Santomasso, Bianca D. ;

Seigel, Carole ;

Spira, Alexander ;

Suarez-Almazor, Maria E. ;

Wang, Yinghong ;

Weber, Jeffrey S. ;

Wolchok, Jedd D. ;

Thompson, John A. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (17) :1714-+

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