Development and characterization of hydroquinone-loaded nanofiber for topical delivery: effect of chitosan

被引：5

作者：

Azarbayjani, Anahita Fathi ^{[1
,2
]}

Talebi, Naimeh ^{[3
]}

Diba, Kambiz ^{[4
]}

机构：

[1] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Sch Pharm, Dept Pharmaceut, POB 5714783734, Orumiyeh, Iran

[3] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran

[4] Urmia Univ Med Sci, Sch Med, Dept Parasitol & Mycol, Orumiyeh, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION | 2019年 / 24卷 / 03期

关键词：

Hydroquinone; chitosan; antifungal activity; stability; nanofiber; ANTIFUNGAL ACTIVITY; ELECTROSPUN; FABRICATION;

D O I：

10.1080/1023666X.2018.1564575

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hydroquinone (HQ) loaded polymer solution was electrospun for its topical application. Nanofibers were then investigated in terms of stability, drug release, and antifungal activity. The effect of chitosan (CS) was investigated on the viscosity, stability, drug release, and antifungal activity of the developed formulation. Results indicate a significantly stable HQ-loaded nanofiber formulation. The addition of CS caused hydration of the drug delivery system and enhanced drug release but reduced its stability. HQ-loaded nanofiber mat showed significant antifungal activity, however, there was no inhibition zone in samples containing CS.

引用

页码：227 / 235

页数：9

共 18 条

[1] Assessing retinol stability in a hydroquinone 4%/retinol 03% cream in the presence of antioxidants and sunscreen under simulated-use conditions: A pilot study [J].

Akhavan, Arash ;

Levitt, Jacob .

CLINICAL THERAPEUTICS, 2008, 30 (03) :543-547

[2] Antifungal activity of low molecular weight chitosan against clinical isolates of Candida spp. [J].

Alburquenque, Claudio ;

Bucarey, Sergio A. ;

Neira-Carrillo, Andronico ;

Urzua, Blanca ;

Hermosilla, German ;

Tapia, Cecilia V. .

MEDICAL MYCOLOGY, 2010, 48 (08) :1018-1023

[3] Chitosan nanofilm and electrospun nanofiber for quick drug release in the treatment of Alzheimer's disease: In vitro and in vivo evaluation [J].

AnjiReddy, Keshireddy ;

Karpagam, Subramanian .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 105 :131-142

[4] Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles [J].

Azarbayjani, Anahita Fathi ;

Khu, Jia Vu ;

Chan, Yew Weng ;

Chan, Sui Yung .

BIOPHARMACEUTICS & DRUG DISPOSITION, 2011, 32 (07) :380-388

[5] Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs [J].

Cheng, Feng ;

Gao, Jing ;

Wang, Lu ;

Hu, Xingyou .

JOURNAL OF APPLIED POLYMER SCIENCE, 2015, 132 (24)

[6] Compatibility study between hydroquinone and the excipients used in semi-solid pharmaceutical forms by thermal and non-thermal techniques [J].

de Barros Lima, Igor Prado ;

Lima, Naiana Gondim P. B. ;

Barros, Denise M. C. ;

Oliveira, Thays S. ;

Mendonca, Candida M. S. ;

Barbosa, Euzebio G. ;

Raffin, Fernanda N. ;

de Lima e Moura, Tulio F. A. ;

Gomes, Ana Paula B. ;

Ferrari, Marcio ;

Aragao, Cicero F. S. .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2015, 120 (01) :719-732

[7] Improvement of skin whitening agents efficiency through encapsulation: Current state of knowledge [J].

Ephrem, Elissa ;

Elaissari, Hamid ;

Greige-Gerges, Helene .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 526 (1-2) :50-68

[8] Preparation and Characterization of Chitosan/Polypyrrole/Sepiolite Nanocomposites [J].

Gulmen, S. Sezin Tarimsal ;

Guvel, Esin Ates ;

Kizilcan, Nilgun .

WORLD CONFERENCE ON TECHNOLOGY, INNOVATION AND ENTREPRENEURSHIP, 2015, :1623-1632

[9] The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin [J].

Hsieh, Pei-Wen ;

Al-Suwayeh, Saleh A. ;

Fang, Chia-Lang ;

Lin, Chwan-Fwu ;

Chen, Chun-Che ;

Fang, Jia-You .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 81 (02) :369-378

[10] Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves [J].

Jurica, Karlo ;

Gobin, Ivana ;

Kremer, Dario ;

Cepo, Dubravka Vitali ;

Grubesic, Renata Jurisic ;

Karaconji, Irena Brcic ;

Kosalec, Ivan .

JOURNAL OF HERBAL MEDICINE, 2017, 8 :17-23

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