The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network
被引:52
作者:
Martucci, Katherine T.
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机构:
Stanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Martucci, Katherine T.
[1
]
Shirer, William R.
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h-index: 0
机构:
Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Shirer, William R.
[2
]
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Bagarinao, Epifanio
[1
]
Johnson, Kevin A.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Johnson, Kevin A.
[1
]
Farmer, Melissa A.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Farmer, Melissa A.
[3
]
Labus, Jennifer S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Dept Med, Los Angeles, CA 90095 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Labus, Jennifer S.
[4
]
Apkarian, A. Vania
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Apkarian, A. Vania
[3
]
Deutsch, Georg
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Radiol, Birmingham, AL USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Deutsch, Georg
[5
]
Harris, Richard E.
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机构:
Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Harris, Richard E.
[6
]
Mayer, Emeran A.
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机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Dept Med, Los Angeles, CA 90095 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Mayer, Emeran A.
[4
]
Clauw, Daniel J.
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h-index: 0
机构:
Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Clauw, Daniel J.
[6
]
Greicius, Michael D.
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机构:
Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Greicius, Michael D.
[2
]
Mackey, Sean C.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USAStanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
Mackey, Sean C.
[1
]
机构:
[1] Stanford Univ, Div Pain Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[3] Northwestern Univ, Dept Physiol, Chicago, IL 60611 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Dept Med, Los Angeles, CA 90095 USA
[5] Univ Alabama Birmingham, Dept Radiol, Birmingham, AL USA
[6] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA
Altered resting-state (RS) brain activity, as a measure of functional connectivity (FC), is commonly observed in chronic pain. Identifying a reliable signature pattern of altered RS activity for chronic pain could provide strong mechanistic insights and serve as a highly beneficial neuroimaging-based diagnostic tool. We collected and analyzed RS functional magnetic resonance imaging data from female patients with urologic chronic pelvic pain syndrome (N = 45) and matched healthy participants (N 5 45) as part of an NIDDK-funded multicenter project (www.mappnetwork.org). Using dual regression and seed-based analyses, we observed significantly decreased FC of the default mode network to 2 regions in the posterior medial cortex (PMC): the posterior cingulate cortex (PCC) and the left precuneus (threshold-free cluster enhancement, family-wise error corrected P < 0.05). Further investigation revealed that patients demonstrated increased FC between the PCC and several brain regions implicated in pain, sensory, motor, and emotion regulation processes (eg, insular cortex, dorsolateral prefrontal cortex, thalamus, globus pallidus, putamen, amygdala, hippocampus). The left precuneus demonstrated decreased FC to several regions of pain processing, reward, and higher executive functioning within the prefrontal (orbitofrontal, anterior cingulate, ventromedial prefrontal) and parietal cortices (angular gyrus, superior and inferior parietal lobules). The altered PMC connectivity was associated with several phenotype measures, including pain and urologic symptom intensity, depression, anxiety, quality of relationships, and self-esteem levels in patients. Collectively, these findings indicate that in patients with urologic chronic pelvic pain syndrome, regions of the PMC are detached from the default mode network, whereas neurological processes of self-referential thought and introspection may be joined to pain and emotion regulatory processes.
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页码:1755 / 1764
页数:10
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机构:
Stanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Johnson, Kevin A.
Martucci, Katherine T.
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h-index: 0
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Stanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Martucci, Katherine T.
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Ichesco, Eric
Farmer, Melissa A.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Farmer, Melissa A.
Labus, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Pain & Interocept Network PAIN, Gail & Gerald Oppenheimer Family Ctr Neurobiol St, Los Angeles, CA 90095 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Labus, Jennifer
Ness, Timothy J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Anesthesiol, Birmingham Med Ctr, Birmingham, AL USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Ness, Timothy J.
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Harris, Richard
Deutsch, Georg
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Radiol, Birmingham Med Ctr, Birmingham, AL USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Deutsch, Georg
Apkarian, A. Vania
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Apkarian, A. Vania
Mayer, Emeran A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Pain & Interocept Network PAIN, Gail & Gerald Oppenheimer Family Ctr Neurobiol St, Los Angeles, CA 90095 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Mayer, Emeran A.
Clauw, Daniel J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Anesthesiol, Chron Pain & Fatigue Res Ctr, Ann Arbor, MI 48109 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Clauw, Daniel J.
Mackey, Sean
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h-index: 0
机构:
Stanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Baliki, Marwan N.
Geha, Paul Y.
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h-index: 0
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Northwestern Univ, Dept Physiol, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Geha, Paul Y.
Apkarian, A. Vania
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h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Northwestern Univ, Dept Anesthesia, Chicago, IL 60611 USA
Northwestern Univ, Dept Surg, Chicago, IL 60611 USA
Northwestern Univ, Lurie Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Apkarian, A. Vania
Chialvo, Dante R.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
机构:
Stanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Johnson, Kevin A.
Martucci, Katherine T.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Martucci, Katherine T.
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Ichesco, Eric
Farmer, Melissa A.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Farmer, Melissa A.
Labus, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Pain & Interocept Network PAIN, Gail & Gerald Oppenheimer Family Ctr Neurobiol St, Los Angeles, CA 90095 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Labus, Jennifer
Ness, Timothy J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Anesthesiol, Birmingham Med Ctr, Birmingham, AL USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Ness, Timothy J.
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Harris, Richard
Deutsch, Georg
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Radiol, Birmingham Med Ctr, Birmingham, AL USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Deutsch, Georg
Apkarian, A. Vania
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Apkarian, A. Vania
Mayer, Emeran A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Pain & Interocept Network PAIN, Gail & Gerald Oppenheimer Family Ctr Neurobiol St, Los Angeles, CA 90095 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Mayer, Emeran A.
Clauw, Daniel J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Anesthesiol, Chron Pain & Fatigue Res Ctr, Ann Arbor, MI 48109 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Clauw, Daniel J.
Mackey, Sean
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Baliki, Marwan N.
Geha, Paul Y.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Geha, Paul Y.
Apkarian, A. Vania
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Northwestern Univ, Dept Anesthesia, Chicago, IL 60611 USA
Northwestern Univ, Dept Surg, Chicago, IL 60611 USA
Northwestern Univ, Lurie Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
Apkarian, A. Vania
Chialvo, Dante R.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Physiol, Chicago, IL 60611 USANorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA