The effects of acute tryptophan depletion on costly information sampling: impulsivity or aversive processing?

被引:24
作者
Crockett, M. J. [1 ,3 ]
Clark, L. [1 ,3 ]
Smillie, L. D. [2 ]
Robbins, T. W. [1 ,3 ]
机构
[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
[2] Univ Melbourne, Melbourne, Vic, Australia
[3] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
Serotonin; Punishment; Impulsivity; Behavioural inhibition; Tryptophan; Decision; making; Aversive processing; Depression; Anxiety; AMINO-ACID MIXTURES; REFLECTION-IMPULSIVITY; BEHAVIORAL-INHIBITION; BRAIN TRYPTOPHAN; PERSONALITY-DISORDER; SERUM TRYPTOPHAN; RAPID DEPLETION; CONSTRUAL LEVEL; DORSAL RAPHE; SEROTONIN;
D O I
10.1007/s00213-011-2577-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale The neurotransmitter serotonin (5-HT) has been implicated in both aversive processing and impulsivity. Reconciling these accounts, recent studies have demonstrated that 5-HT is important for punishment-induced behavioural inhibition. These studies focused on situations where actions lead directly to punishments. However, decision-making often involves making tradeoffs between small 'local' costs and larger 'global' losses. Objective We aimed to distinguish whether 5-HT promotes avoidance of local losses, global losses, or both, in contrast to an overall effect on reflection impulsivity. We further examined the influence of individual differences in sub-clinical depression, anxiety and impulsivity on global and local loss avoidance. Methods Healthy volunteers (N = 21) underwent an acute tryptophan depletion procedure in a double-blind, placebo-controlled crossover design. We measured global and local loss avoidance in a decision-making task where subjects could sample information at a small cost to avoid making incorrect decisions, which resulted in large losses. Results Tryptophan depletion removed the suppressive effects of small local costs on information sampling behaviour. Sub-clinical depressive symptoms produced effects on information sampling similar to (but independent from) those of tryptophan depletion. Dispositional anxiety was related to global loss avoidance. However, trait impulsivity was unrelated to information sampling. Conclusions The current findings are consistent with recent theoretical work that characterises 5-HT as pruning a tree of potential decisions, eliminating options expected to lead to aversive outcomes. Our results extend this account by proposing that 5-HT promotes reflexive avoidance of relatively immediate aversive outcomes, potentially at the expense of more globally construed future losses.
引用
收藏
页码:587 / 597
页数:11
相关论文
共 62 条
[1]   Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus [J].
Amat, J ;
Baratta, MV ;
Paul, E ;
Bland, ST ;
Watkins, LR ;
Maier, SF .
NATURE NEUROSCIENCE, 2005, 8 (03) :365-371
[2]   Effect of acute tryptophan depletion on noradrenaline and dopamine in the rat brain [J].
Ardis, T. C. ;
Cahir, M. ;
Elliott, J. J. ;
Bell, R. ;
Reynolds, G. P. ;
Cooper, S. J. .
JOURNAL OF PSYCHOPHARMACOLOGY, 2009, 23 (01) :51-55
[3]  
Beck A.T., 1996, Manual for the BDI-II, DOI DOI 10.1037/T00742-000
[4]   RAPID DEPLETION OF SERUM TRYPTOPHAN, BRAIN TRYPTOPHAN, SEROTONIN AND 5-HYDROXYINDOLEACETIC ACID BY A TRYPTOPHAN-FREE DIET [J].
BIGGIO, G ;
FADDA, F ;
FANNI, P ;
TAGLIAMONTE, A ;
GESSA, GL .
LIFE SCIENCES, 1974, 14 (07) :1321-1329
[5]   Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin [J].
Boureau, Y-Lan ;
Dayan, Peter .
NEUROPSYCHOPHARMACOLOGY, 2011, 36 (01) :74-97
[6]   Serotonin and Dopamine Play Complementary Roles in Gambling to Recover Losses [J].
Campbell-Meiklejohn, Daniel ;
Wakeley, Judi ;
Herbert, Vanessa ;
Cook, Jennifer ;
Scollo, Paolo ;
Ray, Manaan Kar ;
Selvaraj, Sudhakar ;
Passingham, Richard E. ;
Cowen, Phillip ;
Rogers, Robert D. .
NEUROPSYCHOPHARMACOLOGY, 2011, 36 (02) :402-410
[7]  
Carpenter LL, 1998, NEUROPSYCHOPHARMACOL, V19, P26
[8]   BEHAVIORAL-INHIBITION, BEHAVIORAL ACTIVATION, AND AFFECTIVE RESPONSES TO IMPENDING REWARD AND PUNISHMENT - THE BIS BAS SCALES [J].
CARVER, CS ;
WHITE, TL .
JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1994, 67 (02) :319-333
[9]   Roles of 5-HT1A receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model [J].
Cervo, L ;
Mocaër, E ;
Bertaglia, A ;
Samanin, R .
NEUROPHARMACOLOGY, 2000, 39 (06) :1037-1043
[10]   Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity [J].
Clark, L ;
Roiser, JP ;
Cools, R ;
Rubinsztein, DC ;
Sahakian, BJ ;
Robbins, TW .
PSYCHOPHARMACOLOGY, 2005, 182 (04) :570-578