A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv.

被引：19

作者：

Li, Chuangjun ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Wang, Chao ^{[1
,2
]}

Yang, Jingzhi ^{[1
,2
]}

Ye, Fei ^{[1
,2
]}

Tian, Jinying ^{[1
,2
]}

Si, Yikang ^{[1
,2
]}

Zhang, Dongming ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 12期

关键词：

Eucommia ulmoides Oliv; nor-triterpenoid; ulmoidol A; absolute configuration; ECD; PTPIB; MEGASTIGMANE GLYCOSIDES; CONSTITUENTS; SESQUILIGNAN; BARK;

D O I：

10.3390/molecules171213960

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new ursane-type nortriterpenoid, (11S,12S)-4-methyl-11,12-epoxy-2-hydroxy-3-oxoursa-1,4-dine-28-oic acid gamma-lactone (1), named ulmoidol A, together with ten known compounds: ulmoidol (2), corosolic acid (3), 2 alpha,3 alpha-dihydroxy-24-nor-4(23), 12-oleanadien-28-oic acid (4), oleanolic acid (5), ursolic acid (6), cycloart-3 beta, 25-diol (7), foliasalacioside B1 (8), (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one-9-O-alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranoside (9), (6R,7E,9R)-9-hydroxy-4,7-megastigma-dien-3-one-9-O-alpha-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranoside (10), and quercetin 3-O-sambubioside (11) were isolated from the leaves of Eucommia ulmoides Oliv. The structure of compound 1 was determined by extensive spectroscopic analysis, and its absolute configuration was determined by CD experiments and a computational method. Compounds 3, 4, 7-10 were isolated from this plant for the first time. Compounds 3 and 4 showed inhibition to PTPIB activities, with IC50 values of 0.69 and 3.98 mu M, respectively.

引用

页码：13960 / 13968

页数：9

共 25 条

[21] Studies on the chemical constituents of green leaves of Eucommia ulmoides Oliv. [J].