A case report of placental mesenchymal dysplasia with an increased VEGF-D expression

被引：18

作者：

Kotani, T. ^{[1
]}

Sumigama, S. ^{[1
]}

Tsuda, H. ^{[1
]}

Mano, Y. ^{[1
]}

Yamamoto, E. ^{[1
]}

Iwase, A. ^{[1
]}

Shimoyama, Y. ^{[2
]}

Nagasaka, T. ^{[2
]}

Hayakawa, H. ^{[3
]}

Yamamoto, T. ^{[4
]}

Ino, K. ^{[5
]}

Kikkawa, F. ^{[1
]}

机构：

[1] Nagoya Univ, Dept Obstet & Gynecol, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ Hosp, Dept Pathol & Lab Med, Showa Ku, Nagoya, Aichi, Japan

[3] Kasugai Municipal Hosp, Dept Obstet & Gynecol, Kasugai, Aichi, Japan

[4] Nagoya Univ, Dept Legal Med & Bioeth, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[5] Wakayama Med Univ, Dept Obstet & Gynecol, Wakayama, Japan

来源：

PLACENTA | 2012年 / 33卷 / 10期

关键词：

VEGF-D; X-chromosome; IUGR; HAMARTOMA;

D O I：

10.1016/j.placenta.2012.07.015

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The pathogenesis of placental mesenchymal dysplasia (PMD) remains unclear. This report presents a case of PMD with a female fetus complicated with intrauterine growth restriction (IUGR). The ultrasound findings were similar to molar pregnancies, but PMD was suspected based on the presence of low beta-hCG levels and a normal karyotype. After delivery, pathological examination of the placenta showed dilated villi and thick-walled vessels lacking trophoblast proliferation, which thus led to a diagnosis of PMD. The VEGF-D (Xp22.31) mRNA expression was found to have increased in the abnormal villi. Whether this is an incidental or X-linked gene specific event in, IUGR complicated, PMD pathogenesis warrants further investigation of VEGF-D expression in PMD. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：888 / 891

页数：4

共 13 条

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