Protein modifications in transcription elongation

被引：53
作者：
Fuchs, Stephen M. [2 ]
Laribee, R. Nicholas [3 ]
Strahl, Brian D. [1 ,2 ]
机构：
[1] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[3] Univ Tennessee, Hlth Sci Ctr, Dept Pathol & Lab Med, Memphis, TN 38163 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 01期
关键词：
Posttranslational modification; Histone; Transcription; RNA polymerase II; Chromatin; RNA-POLYMERASE-II; C-TERMINAL DOMAIN; CHROMATIN-REMODELING COMPLEX; HISTONE H2B UBIQUITYLATION; REGULATES H3 METHYLATION; SACCHAROMYCES-CEREVISIAE; LYSINE-4; METHYLATION; ARGININE METHYLATION; PHD FINGER; DNA-DAMAGE;
D O I：
10.1016/j.bbagrm.2008.07.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Posttranslational modifications (PTMs) of proteins play essential roles in regulating signaling, protein-protein modifications and subcellular localization. In this review, we focus on posttranslational modification of histones and RNA polymerase II (RNAPII) and their roles in gene transcription. A survey of the basic features of PTMs is provided followed by a more detailed account of how PTMs on histones and RNAPII regulate transcription in the model organism Saccharomyces cerevisiae. We emphasize the interconnections between histone and RNAPII PTMs and speculate upon the larger role PTMs have in regulating protein function in the cell. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：26 / 36
页数：11
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