Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I

被引：41

作者：

Caruso, Anna ^{[1
]}

Chimento, Adele ^{[2
]}

El-Kashef, Hussein ^{[3
]}

Lancelot, Jean-Charles ^{[4
]}

Panno, Antonella ^{[1
]}

Pezzi, Vincenzo ^{[2
]}

Saturnino, Carmela ^{[5
]}

Sinicropi, Maria Stefania ^{[1
]}

Sirianni, Rosa ^{[2
]}

Rault, Sylvain ^{[4
]}

机构：

[1] Univ Calabria, Dept Pharmaceut Sci, I-87036 Arcavacata Di Rende, CS, Italy

[2] Univ Calabria, Dept Pharmacobiol, I-87036 Arcavacata Di Rende, CS, Italy

[3] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

[4] Univ Caen Basse Normandie, Ctr Etud & Rech Medicament Normandie, UFR Sci Pharmaceut, Caen, France

[5] Univ Salerno, Dept Pharmaceut & Biomed Sci, Fisciano, SA, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2012年 / 27卷 / 04期

关键词：

Carbazoles; anticancer; MCF-7 cell line; Ishikawa cell line; ENDOMETRIAL CANCER; CARBAZOLE DERIVATIVES; EFFICIENT SYNTHESIS; LINE; GROWTH; CYTOTOXICITY; AGENTS;

D O I：

10.3109/14756366.2011.603132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.

引用

页码：609 / 613

页数：5

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