Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment

被引：26

作者：

Cotugno, Nicola ^{[2
]}

Douagi, Iyadh ^{[3
]}

Rossi, Paolo ^{[1
,2
]}

Palma, Paolo ^{[1
]}

机构：

[1] Children Hosp Bambino Gesu, DPUO, Univ Dept Pediat, I-00165 Rome, Italy

[2] Univ Roma Tor Vergata, I-00133 Rome, Italy

[3] Karolinska Inst, Dept Med, SE-14186 Stockholm, Sweden

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; IMMUNODEFICIENCY-VIRUS-INFECTION; PLASMA VIRAL LOAD; HIV-1-INFECTED CHILDREN; 1-INFECTED CHILDREN; PROTEASE INHIBITOR; INFLUENZA VACCINATION; HUMORAL IMMUNITY; INTERFERON-GAMMA; IL-21; RECEPTOR;

D O I：

10.1155/2012/805151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Today, HIV-infected children who have access to treatment face a chronic rather than a progressive and fatal disease. As a result, new challenges are emerging in the field. Recent lines of evidence outline several factors that can differently affect the ability of the immune system to fully reconstitute and to mount specific immune responses in children receiving HAART. In this paper, we review the underlying mechanisms of immune reconstitution after HAART initiation among vertically HIV-infected children analyzing the possible causes of suboptimal responses.

引用

页数：11

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