Methodological considerations in use of the cortisol/DHEA(S) ratio in adolescent populations

被引：22

作者：

Saczawa, Mary E. ^{[1
]}

Graber, Julia A. ^{[1
]}

Brooks-Gunn, Jeanne ^{[2
,3
]}

Warren, Michelle P. ^{[2
]}

机构：

[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA

[2] Columbia Univ, Coll Phys & Surg, New York, NY USA

[3] Columbia Univ, Teachers Coll, New York, NY 10027 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2013年 / 38卷 / 11期

关键词：

Cortisol; DHEA; DHEAS; Ratio; HPA axis; Adolescent; Puberty; Adrenarche; SALIVARY CORTISOL; DEHYDROEPIANDROSTERONE; RHYTHMS; PUBERTY; GIRLS; DHEA;

D O I：

10.1016/j.psyneuen.2013.06.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The cortisol/DHEA(S) ratio has demonstrated utility in studies of HPA activity and psychopathology. However, use of the cortisol/DHEA(S) ratio in adolescent populations requires additional consideration of differential changes in DHEA(S) and cortisol during the course of puberty. This study examines the relationship between pubertal status and individual cortisol and DHEAS levels as well as with the cortisol/DHEAS ratio. Method: Morning salivary cortisol and urinary DHEAS levels were obtained for 267 young adolescents at three time points, each approximately one year apart. Growth curve modeling and repeated measures ANOVA were used to assess the effect of adrenal development on individual hormone levels and on the total ratio. Results: Pubic hair development was a significant predictor of change over time in DHEAS but not cortisol. Development was also a significant predictor of the cortisol/DHEAS ratio when raw cortisol and DHEAS values were used. Conclusions: Our findings indicate that, when DHEAS levels were adjusted to control for pubertal status, the ratio demonstrated stability over time. This finding is in line with the hypothesis that the ratio may tap stable individual differences in HPA functioning. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2815 / 2819

页数：5

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