TYPE 2 DIABETES MELLITUS IN 2013 A central role of the gut in glucose homeostasis

被引：16

作者：

Mingrone, Geltrude ^{[1
]}

Castagneto-Gissey, Lidia ^{[2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy

[2] Univ Roma La Sapienza, Dept Surg, I-00195 Rome, Italy

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2014年 / 10卷 / 02期

关键词：

VERTICAL SLEEVE GASTRECTOMY; BARIATRIC SURGERY; MEDICAL THERAPY; METABOLISM; BYPASS;

D O I：

10.1038/nrendo.2013.241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Metabolic surgery has been proven to be effective in inducing remission of type 2 diabetes mellitus prior to any significant weight reduction. Studies in 2013 have investigated the mechanisms of action of these procedures and have highlighted a central role of the small intestine in the effects on glucose homeostasis.

引用

页码：73 / 74

页数：2

共 10 条

[1] Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes [J].

Breen, Danna M. ;

Rasmussen, Brittany A. ;

Kokorovic, Andrea ;

Wang, Rennian ;

Cheung, Grace W. C. ;

Lam, Tony K. T. .

NATURE MEDICINE, 2012, 18 (06) :950-+

[2] The Effects of Vertical Sleeve Gastrectomy in Rodents Are Ghrelin Independent [J].

Chambers, Adam P. ;

Kirchner, Henriette ;

Wilson-Perez, Hilary E. ;

Willency, Jill A. ;

Hale, John E. ;

Gaylinn, Bruce D. ;

Thorner, Michael O. ;

Pfluger, Paul T. ;

Gutierrez, Jesus A. ;

Tschoep, Matthias H. ;

Sandoval, Darleen A. ;

Seeley, Randy J. .

GASTROENTEROLOGY, 2013, 144 (01) :50-U124

[3] Insulin resistance and hyperinsulinaemia in the development and progression of cancer [J].

Godsland, Ian F. .

CLINICAL SCIENCE, 2010, 118 (5-6) :315-332

[4] Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity [J].

Kumar, Anil ;

Harris, Thurl E. ;

Keller, Susanna R. ;

Choi, Kin M. ;

Magnuson, Mark A. ;

Lawrence, John C., Jr. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (01) :61-70

[5] Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes [J].

Mingrone, Geltrude ;

Panunzi, Simona ;

De Gaetano, Andrea ;

Guidone, Caterina ;

Iaconelli, Amerigo ;

Leccesi, Laura ;

Nanni, Giuseppe ;

Pomp, Alfons ;

Castagneto, Marco ;

Ghirlanda, Giovanni ;

Rubino, Francesco .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (17) :1577-1585

[6] Reprogramming of Intestinal Glucose Metabolism and Glycemic Control in Rats After Gastric Bypass [J].

Saeidi, Nima ;

Meoli, Luca ;

Nestoridi, Eirini ;

Gupta, Nitin K. ;

Kvas, Stephanie ;

Kucharczyk, John ;

Bonab, Ali A. ;

Fischman, Alan J. ;

Yarmush, Martin L. ;

Stylopoulos, Nicholas .

SCIENCE, 2013, 341 (6144) :406-410

[7] Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance [J].

Salinari, Serenella ;

Debard, Cyrille ;

Bertuzzi, Alessandro ;

Durand, Christine ;

Zimmet, Paul ;

Vidal, Hubert ;

Mingrone, Geltrude .

PLOS ONE, 2013, 8 (02)

[8] Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes [J].

Schauer, Philip R. ;

Kashyap, Sangeeta R. ;

Wolski, Kathy ;

Brethauer, Stacy A. ;

Kirwan, John P. ;

Pothier, Claire E. ;

Thomas, Susan ;

Abood, Beth ;

Nissen, Steven E. ;

Bhatt, Deepak L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (17) :1567-1576

[9] Role of Akt/protein kinase B in metabolism [J].

Whiteman, EL ;

Cho, H ;

Birnbaum, MJ .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (10) :444-451

[10] Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency [J].

Wilson-Perez, Hilary E. ;

Chambers, Adam P. ;

Ryan, Karen K. ;

Li, Bailing ;

Sandoval, Darleen A. ;

Stoffers, Doris ;

Drucker, Daniel J. ;

Perez-Tilve, Diego ;

Seeley, Randy J. .

DIABETES, 2013, 62 (07) :2380-2385

← 1 →