Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)-H bonds with aryl halides

被引：124
作者：
Li, Mingliang
Dong, Jiaxing
Huang, Xiaolei
Li, Kaizhi
Wu, Qian
Song, Feijie
You, Jingsong [1 ]
机构：
[1] Sichuan Univ, Minist Educ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 30期
关键词：
C-H BOND; CARBON-HYDROGEN BONDS; DIRECT FUNCTIONALIZATION; NATURAL-PRODUCTS; ALPHA-ARYLATION; ACTIVATION; ALKYLATION; PIPERIDINES; AMINES; ARENES;
D O I：
10.1039/c4cc00716f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this work, we have disclosed the nickel-catalyzed unactivated beta-C(sp(3))-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp(3))-H bond arylation.
引用
收藏
页码：3944 / 3946
页数：3
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