Aqueous hydrotropic solution as an efficient solubilizing agent for andrographolide from andrographis paniculata leaves

被引：19

作者：

Mishra, SP ^{[1
]}

Gaikar, VG ^{[1
]}

机构：

[1] Univ Bombay, Inst Chem Technol, Bombay 400019, Maharashtra, India

来源：

SEPARATION SCIENCE AND TECHNOLOGY | 2006年 / 41卷 / 06期

关键词：

andrographolide; Andrographis paniculata; hydrotropy; sodium cumene sulfonate; sodium salicylate; extraction;

D O I：

10.1080/01496390600633675

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An aqueous solution based extraction process for andrographolide from Andrographis paniculata leaves has been developed using alkyl benzene sulfonates and carboxylates as hydrotropes. The plant cells are permeabilized by the hydrotrope solutions followed by solubilization of andrographolide into the solutions. The extraction and solubilization of andrographolide is affected by structure and concentration of hydrotrope, temperature and particle size. Sodium cumene sulfonate (Na-CS) shows the most efficient solubilization of andrographolide amongst the hydrotropes studied. The solubility of andrographolide increased by two orders of magnitude in Na-CS aqueous solutions and similar to 96% andrographolide extraction was achieved in just 20 min.

引用

页码：1115 / 1134

页数：20

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