Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease

被引：0

作者：

dos Santos, Vanessa V. ^{[1
]}

Rodrigues, Ana Lucia S. ^{[1
,2
]}

De Lima, Thereza C. ^{[3
]}

de Barioglio, Susana R. ^{[4
,5
]}

Raisman-Vozari, Rita ^{[6
]}

Prediger, Rui D. ^{[1
,3
]}

机构：

[1] Univ Fed Santa Catarina, UFSC, Ctr Ciencias Biol, Programa Posgrad Neurociencias, BR-88049900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, UFSC, Ctr Ciencias Biol, Dept Bioquim, BR-88049900 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, UFSC, Ctr Ciencias Biol, Dept Farmacol, BR-88049900 Florianopolis, SC, Brazil

[4] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, RA-5000 Cordoba, Argentina

[5] IFEC CONICET, Cordoba, Argentina

[6] Univ Paris 06, INSERM, Hop La Pitie Salpetriere,UMR 975, Ctr Rech Inst Cerveau & Moelle Epiniere CRICM The, Paris, France

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 38期

关键词：

Ghrelin; neuroprotection; Alzheimer's disease; Parkinson's disease; learning and memory; anxiety; depression; SLEEP BEHAVIOR DISORDER; PHOSPHATIDYLINOSITOL-3-KINASE/AKT/GLYCOGEN SYNTHASE KINASE-3-BETA; SUBTHALAMIC NUCLEUS STIMULATION; HORMONE SECRETAGOGUE RECEPTOR; SPINAL-CORD MOTONEURONS; DEEP BRAIN-STIMULATION; ANXIETY-LIKE BEHAVIOR; DES-ACYL GHRELIN; PLASMA GHRELIN; CELL-DEATH;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ghrelin is a gastric hormone that stimulates growth hormone (GH) secretion and food intake to regulate energy homeostasis and body weight by binding to its receptor, GH secretagogue receptor (GHSR1a), which is most highly expressed in the pituitary and hypothalamus. Nowadays there is considerable evidence showing that the GHSR1a is also expressed in numerous extra-hypothalamic neuronal populations and the physiological role of ghrelin is by far wider than considered before including learning and memory, anxiety, depression and neuroprotection. The present review attempts to provide a comprehensive picture of the role of ghrelin in the central nervous system and to highlight recent findings showing its potential as an innovative therapeutic agent in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.

引用

页码：6773 / 6790

页数：18

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