This article briefly presents a novel concept of regional-level power asymmetry. The concept has been designed to explain a specific phenomenon of contemporary international relations interaction among powerful states under the circumstances of growing importance ascribed to regions. This innovation follows the so-called analytically eclectic research strategy. The strategy is is built upon the main insights of all the principal international relations paradigms (realism, liberalism, and constructivism) with a special emphasis provided for the unifying regional approach. The concept of regional-level power asymmetry not only allows the development of an explicit measurement tool, but it also suggests the guidelines for a broader middle-range theory which could be applied in future empirical research.