Facilitation of memory performance by a novel muscarinic agonist in young and old rats

被引：15

作者：

Ruske, AC ^{[1
]}

White, KG ^{[1
]}

机构：

[1] Univ Otago, Dept Psychol, Dunedin, New Zealand

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1999年 / 63卷 / 04期

关键词：

rats; memory; rate of forgetting; initial discriminability; delayed matching-to-sample; cholinergic system; age; AF150(S); muscarinic agonist;

D O I：

10.1016/S0091-3057(99)00037-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

AF150(S), a partial M1 muscarinic receptor agonist, was tested for its ability to improve performance in rats in a delayed matching-to-position task. Young and old rats received intraperitoneal injections of 0, 1, and 4 mg/kg of AF150(S). AF150(S) significantly enhanced matching accuracy for both young and old rats. Fits of exponential functions to discriminability measures showed that the enhancement was manifest as a reduction in the rate of forgetting. These results indicate that AF150(S) may be a useful therapeutic agent for improving cognitive function. (C) 1999 Elsevier Science Inc.

引用

页码：663 / 667

页数：5

共 38 条

[1] SHORT-TERM-MEMORY IN RHESUS-MONKEY - DISRUPTION FROM ANTI-CHOLINERGIC SCOPOLAMINE [J].