Relapsing Thrombotic Thrombocytopenic Purpura (TTP) in a Patient Treated with Infliximab for Chronic Uveitis

被引：3

作者：

Mopuru, Renuka ^{[1
]}

Chaturvedi, Shruti ^{[2
]}

Burkholder, Bryn M. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2022年 / 30卷 / 01期

关键词：

Thrombotic thrombocytopenic purpura; infliximab; uveitis; ADAMTS13; drug-induced thrombotic microangiopathy; FACTOR-CLEAVING PROTEASE; MICROANGIOPATHY;

D O I：

10.1080/09273948.2020.1797117

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose To report a case of relapsing thrombotic thrombocytopenic purpura (TTP) in a patient treated with infliximab for chronic uveitis. Case report A 57-year-old African American woman with chronic anterior and intermediate uveitis, treated with infliximab for more than 1 year, presented with fatigue, dark colored urine, and ecchymosis on her extremities. She was diagnosed with thrombotic thrombocytopenic purpura (TTP) and recovered after treatment. After a remission period of 8 months, she was treated again with infliximab for recurrent intraocular inflammation. She developed a relapse of TTP 4 weeks after reintroducing infliximab. Conclusion Relapsing thrombotic thrombocytopenic purpura can be a rare complication associated with infliximab. To our knowledge, it has not been reported in the literature to date.

引用

页码：241 / 243

页数：3

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