Mammary gland carcinogenesis by food-derived heterocyclic amines:: Metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

被引：23
作者：
Snyderwine, EG [1 ]
机构：
[1] NCI, Chem Carcinogenesis Sect, Expt Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA
来源：
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2002年 / 39卷 / 2-3期
关键词：
mammary gland; carcinogenesis; heterocyclic amines; PhIP; metabolism; DNA adduct;
D O I：
10.1002/em.10053
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds found in cooked meats. Several HCAs are mammary gland carcinogens in rats. Of these compounds, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the major one present in the human diet. This report reviews the studies on rat mammary gland carcinogenesis by HCAs; discusses what is currently known regarding mechanisms of mammary gland carcinogenesis of PhlP, especially the significance of metabolic processing; and further highlights the evidence for the possible role of PhIP in human breast cancer. Published 2002 Wiley-Liss, lnc.(dagger)
引用
收藏
页码：165 / 170
页数：6
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