Is there a relationship between nonsteroidal antiinflammatory drug use and gastroesophageal reflux disease?

Gastroesophageal reflux disease (GERD) is all the symptoms caused by reflux of stomach contents into the esophagus. It can be defined as the passage of a portion of the gastric contents into the esophagus. In developed countries GERD has become a major health problem using large financial resources and at the same time reduces quality of life. GERD prevalence in our country is not specified, but it is probably higher than reported. There are medications with relaxing effect of lower esophageal sphincter well documented that may influence the incidence of GERD present such as nitrates, anticholinergics, beta-adrenergic agonists, benzodiazepines nonsteroidal antiinflamatory drugs (NSAIDs) and calcium channel blockers. With this in mind we wanted to see the relationship between intake of NSAIDs determine the presence of gastroesophageal reflux (GER) more than 5% of the time what is pathologically. Were included in the study 41 patients who were presented in the 3rd Medical Clinic ClujNapoca during the period March 2012 - March 2015 and they did esophageal pH-metry / 24h. They were divided into two groups: I- patients receiving treatment with NSAIDs (16 patients) and II patients who not recived treatement with NSAIDs (25 patients). Analysis was performed with R software version 3.1.2 (10/31/2014). In group I, 50% of patients receiving treatment with NSAIDs had GERD and 50% had no GERD. In group II, 36% had GERD and 64% had no GERD. We tested the association between the NSAID and the GERD and there was obtained p=0.37 using Chi square test, which means that there is a statistically significant association between the use of NSAIDs, and the presence of GERD. GERD risk that is present is 1.39 times (14%) higher in patients receiving treatment with NSAIDs to others.