Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations

被引：185

作者：

Marsh, S

Collie-Duguid, ESR

Li, T

Liu, XH

McLeod, HL ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland

[2] Inst Psychiat, Mol Genet Sect, London SE5 8AF, England

[3] W China Univ Med Sci, Chengdu 610041, Sichuan, Peoples R China

来源：

GENOMICS | 1999年 / 58卷 / 03期

基金：

英国惠康基金;

关键词：

thymidylate synthase; polymorphism; ethnic groups; Asian; pharmacogenetics;

D O I：

10.1006/geno.1999.5833

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected in vitro expression levels of the gene. We evaluated the influence of ethnicity on TSER genotype. Allele frequency was similar in Caucasian and Southwest Asian subjects. However, homozygous triple repeat subjects were tn-ice as common in Chinese subjects (67%) than in Caucasian subjects (38%). This demonstrates significant ethnic variation in a TS gene regulatory element which may have significant impact on pyrimidine homeostasis and drug therapy. (C) 1999 Academic Press.

引用

收藏

页码：310 / 312

页数：3

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