Bridge to Recovery Understanding the Disconnect Between Clinical and Biological Outcomes

被引:92
作者
Drakos, Stavros G. [1 ,2 ,3 ,4 ,5 ,6 ]
Kfoury, Abdallah G. [2 ,3 ,4 ,5 ]
Stehlik, Josef [2 ,3 ,5 ]
Selzman, Craig H. [2 ,3 ,5 ]
Reid, Bruce B. [2 ,3 ,4 ,5 ]
Terrovitis, John V. [6 ]
Nanas, John N. [6 ]
Li, Dean Y. [2 ,3 ]
机构
[1] Univ Utah, Heart Failure Program, Div Cardiol, Sch Med, Salt Lake City, UT 84132 USA
[2] Univ Utah, Sch Med, Div Cardiothorac Surg, Salt Lake City, UT 84132 USA
[3] Univ Utah, Sch Med, Div Mol Med, Salt Lake City, UT 84132 USA
[4] Intermt Med Ctr, Cardiovasc Dept, Salt Lake City, UT USA
[5] UTAH Cardiac Transplant Program, Salt Lake City, UT USA
[6] Univ Athens, Div Cardiol 3, Athens, Greece
基金
美国国家卫生研究院;
关键词
cardiac recovery; heart failure; heart-assist devices; mechanical unloading; cardiac remodeling; ventricular; reverse modeling; VENTRICULAR ASSIST DEVICE; MECHANICAL CIRCULATORY SUPPORT; STAGE HEART-FAILURE; CONTINUOUS-FLOW; MYOCARDIAL RECOVERY; EXTRACELLULAR-MATRIX; MOLECULAR-CHANGES; PULSATILE-FLOW; LVAD SUPPORT; EXPRESSION;
D O I
10.1161/CIRCULATIONAHA.111.040261
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:230 / 241
页数:12
相关论文
共 103 条
  • [1] Combination Therapy with Pulsatile Left Ventricular Assist Device, Heart Failure Medication and Clenbuterol in Chronic Heart Failure: Results from HARPS
    Aaronson, K. D.
    Pagani, F. D.
    Maybaum, S. W.
    Feldman, D. S.
    Bogaev, R. C.
    O'Connell, J. B.
    Boyce, S. W.
    McGee, E. W.
    Sun, B. C.
    Goldstein, D. J.
    Frazier, O. H.
    Myles, J. D.
    Weatherwax, K. J.
    Basobas, L.
    McGowan, L.
    Farrar, D. J.
    Yacoub, M. H.
    Birks, E. J.
    Miller, L. W.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (04) : S8 - S9
  • [2] Incomplete Recovery of Myocyte Contractile Function Despite Improvement of Myocardial Architecture With Left Ventricular Assist Device Support
    Ambardekar, Amrut V.
    Walker, John S.
    Walker, Lori A.
    Cleveland, Joseph C., Jr.
    Lowes, Brian D.
    Buttrick, Peter M.
    [J]. CIRCULATION-HEART FAILURE, 2011, 4 (04) : 425 - +
  • [3] Reverse Remodeling With Left Ventricular Assist Devices A Review of Clinical, Cellular, and Molecular Effects
    Ambardekar, Amrut V.
    Buttrick, Peter M.
    [J]. CIRCULATION-HEART FAILURE, 2011, 4 (02) : 224 - 233
  • [4] Reversal of metallothionein expression is different throughout the human myocardium after prolonged left-ventricular mechanical support
    Baba, HA
    Grabellus, F
    August, C
    Plenz, G
    Takeda, A
    Tjan, TDT
    Schmid, C
    Deng, MC
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2000, 19 (07) : 668 - 674
  • [5] Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support
    Baba, Hideo A.
    Wohlschlaeger, Jeremias
    [J]. CURRENT CARDIOLOGY REVIEWS, 2008, 4 (03) : 157 - 169
  • [6] Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy
    Barton, PJR
    Felkin, LE
    Birks, EJ
    Cullen, ME
    Banner, NR
    Grindle, S
    Hall, JL
    Miller, LW
    Yacoub, MH
    [J]. CIRCULATION, 2005, 112 (09) : I46 - I50
  • [7] Gene proriling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support
    Birks, EJ
    Hall, JL
    Barton, PJR
    Grindle, S
    Latif, N
    Hardy, JP
    Rider, JE
    Banner, NR
    Khaghani, A
    Miller, LW
    Yacoub, MH
    [J]. CIRCULATION, 2005, 112 (09) : I57 - I64
  • [8] Left ventricular assist device and drug therapy for the reversal of heart failure
    Birks, Emma J.
    Tansley, Patrick D.
    Hardy, James
    George, Robert S.
    Bowles, Christopher T.
    Burke, Margaret
    Banner, Nicholas R.
    Khaghani, Asghar
    Yacoub, Magdi H.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (18) : 1873 - 1884
  • [9] Reversal of Severe Heart Failure With a Continuous-Flow Left Ventricular Assist Device and Pharmacological Therapy A Prospective Study
    Birks, Emma J.
    George, Robert S.
    Hedger, Mike
    Bahrami, Toufan
    Wilton, Penny
    Bowles, Christopher T.
    Webb, Carole
    Bougard, Robert
    Amrani, Mohammed
    Yacoub, Magdi H.
    Dreyfus, Gilles
    Khaghani, Asghar
    [J]. CIRCULATION, 2011, 123 (04) : 381 - U299
  • [10] Diffierential gene expression and genomic patient stratification following left ventricular assist device support
    Blaxall, BC
    Tschannen-Moran, BM
    Milano, CA
    Koch, WJ
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (07) : 1096 - 1106