Bridge to Recovery Understanding the Disconnect Between Clinical and Biological Outcomes

被引：94
作者：
Drakos, Stavros G. [1 ,2 ,3 ,4 ,5 ,6 ]
Kfoury, Abdallah G. [2 ,3 ,4 ,5 ]
Stehlik, Josef [2 ,3 ,5 ]
Selzman, Craig H. [2 ,3 ,5 ]
Reid, Bruce B. [2 ,3 ,4 ,5 ]
Terrovitis, John V. [6 ]
Nanas, John N. [6 ]
Li, Dean Y. [2 ,3 ]
机构：
[1] Univ Utah, Heart Failure Program, Div Cardiol, Sch Med, Salt Lake City, UT 84132 USA
[2] Univ Utah, Sch Med, Div Cardiothorac Surg, Salt Lake City, UT 84132 USA
[3] Univ Utah, Sch Med, Div Mol Med, Salt Lake City, UT 84132 USA
[4] Intermt Med Ctr, Cardiovasc Dept, Salt Lake City, UT USA
[5] UTAH Cardiac Transplant Program, Salt Lake City, UT USA
[6] Univ Athens, Div Cardiol 3, Athens, Greece
来源：
CIRCULATION | 2012年 / 126卷 / 02期
基金：
美国国家卫生研究院;
关键词：
cardiac recovery; heart failure; heart-assist devices; mechanical unloading; cardiac remodeling; ventricular; reverse modeling; VENTRICULAR ASSIST DEVICE; MECHANICAL CIRCULATORY SUPPORT; STAGE HEART-FAILURE; CONTINUOUS-FLOW; MYOCARDIAL RECOVERY; EXTRACELLULAR-MATRIX; MOLECULAR-CHANGES; PULSATILE-FLOW; LVAD SUPPORT; EXPRESSION;
D O I：
10.1161/CIRCULATIONAHA.111.040261
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：230 / 241
页数：12
相关论文
共 103 条
[1]   Combination Therapy with Pulsatile Left Ventricular Assist Device, Heart Failure Medication and Clenbuterol in Chronic Heart Failure: Results from HARPS [J].
Aaronson, K. D. ;
Pagani, F. D. ;
Maybaum, S. W. ;
Feldman, D. S. ;
Bogaev, R. C. ;
O'Connell, J. B. ;
Boyce, S. W. ;
McGee, E. W. ;
Sun, B. C. ;
Goldstein, D. J. ;
Frazier, O. H. ;
Myles, J. D. ;
Weatherwax, K. J. ;
Basobas, L. ;
McGowan, L. ;
Farrar, D. J. ;
Yacoub, M. H. ;
Birks, E. J. ;
Miller, L. W. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (04) :S8-S9
[2]   Incomplete Recovery of Myocyte Contractile Function Despite Improvement of Myocardial Architecture With Left Ventricular Assist Device Support [J].
Ambardekar, Amrut V. ;
Walker, John S. ;
Walker, Lori A. ;
Cleveland, Joseph C., Jr. ;
Lowes, Brian D. ;
Buttrick, Peter M. .
CIRCULATION-HEART FAILURE, 2011, 4 (04) :425-+
[3]   Reverse Remodeling With Left Ventricular Assist Devices A Review of Clinical, Cellular, and Molecular Effects [J].
Ambardekar, Amrut V. ;
Buttrick, Peter M. .
CIRCULATION-HEART FAILURE, 2011, 4 (02) :224-233
[4]   Reversal of metallothionein expression is different throughout the human myocardium after prolonged left-ventricular mechanical support [J].
Baba, HA ;
Grabellus, F ;
August, C ;
Plenz, G ;
Takeda, A ;
Tjan, TDT ;
Schmid, C ;
Deng, MC .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2000, 19 (07) :668-674
[5]   Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support [J].
Baba, Hideo A. ;
Wohlschlaeger, Jeremias .
CURRENT CARDIOLOGY REVIEWS, 2008, 4 (03) :157-169
[6]   Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy [J].
Barton, PJR ;
Felkin, LE ;
Birks, EJ ;
Cullen, ME ;
Banner, NR ;
Grindle, S ;
Hall, JL ;
Miller, LW ;
Yacoub, MH .
CIRCULATION, 2005, 112 (09) :I46-I50
[7]   Gene proriling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support [J].
Birks, EJ ;
Hall, JL ;
Barton, PJR ;
Grindle, S ;
Latif, N ;
Hardy, JP ;
Rider, JE ;
Banner, NR ;
Khaghani, A ;
Miller, LW ;
Yacoub, MH .
CIRCULATION, 2005, 112 (09) :I57-I64
[8]   Left ventricular assist device and drug therapy for the reversal of heart failure [J].
Birks, Emma J. ;
Tansley, Patrick D. ;
Hardy, James ;
George, Robert S. ;
Bowles, Christopher T. ;
Burke, Margaret ;
Banner, Nicholas R. ;
Khaghani, Asghar ;
Yacoub, Magdi H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (18) :1873-1884
[9]   Reversal of Severe Heart Failure With a Continuous-Flow Left Ventricular Assist Device and Pharmacological Therapy A Prospective Study [J].
Birks, Emma J. ;
George, Robert S. ;
Hedger, Mike ;
Bahrami, Toufan ;
Wilton, Penny ;
Bowles, Christopher T. ;
Webb, Carole ;
Bougard, Robert ;
Amrani, Mohammed ;
Yacoub, Magdi H. ;
Dreyfus, Gilles ;
Khaghani, Asghar .
CIRCULATION, 2011, 123 (04) :381-U299
[10]   Diffierential gene expression and genomic patient stratification following left ventricular assist device support [J].
Blaxall, BC ;
Tschannen-Moran, BM ;
Milano, CA ;
Koch, WJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (07) :1096-1106
12345678910