Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank

被引：3

作者：

Mukhina, A. Yu ^{[1
]}

Mishina, E. S. ^{[1
]}

Bobyntsev, I. I. ^{[1
]}

Medvedeva, O. A. ^{[1
]}

Svishcheva, M., V ^{[1
]}

Kalutskii, P., V ^{[1
]}

Andreeva, L. A. ^{[2
]}

Myasoedov, N. F. ^{[2
]}

机构：

[1] Kursk State Med Univ, Minist Hlth Russian Federat, Kursk, Russia

[2] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 02期

关键词：

Selank; restraint stress; corticosterone; colon; dysbiosis; HIPPOCAMPUS; MICROBIOTA; BRAIN;

D O I：

10.1007/s10517-020-04868-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 mu g/kg 15 min before stress exposure. In rats subjected to stress, signs of atrophy, inflammatory reaction, and changes in the number and functional activity of mast cells were observed against the background of increased corticosterone level. Selank administration led to a decrease in corticosterone levels, reduced pathomorphological manifestations of stress exposure, and accelerated adaptation. These effects were presumably realized due to multifunctional biological effects of Selank.

引用

页码：281 / 285

页数：5

共 15 条

[1]

Andreeva LA, 2011, INFEKTSIYA IMMUN, V1, P171

[2]

Apartsin K.A., 2006, ALLERGOL IMMUNOL, V7, P429

[3] Role of the Microbiota in Immunity and Inflammation [J].

Belkaid, Yasmine ;

Hand, Timothy W. .

CELL, 2014, 157 (01) :121-141

[4] Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation [J].

Bonaz, Bruno ;

Sinniger, Valerie ;

Pellissier, Sonia .

JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (20) :5781-5790

[5] Transcriptome Alteration in Hippocampus under the Treatment of Tuftsin Analog Selank [J].

Kolomin, T. A. ;

Agapova, T. Yu. ;

Agniullin, Ya. V. ;

Shram, S. I. ;

Shadrina, M. I. ;

Slominsky, P. A. ;

Limborska, S. A. ;

Myasoedov, N. F. .

ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2013, 63 (03) :365-374

[6] Transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide selank [J].

Kolomin, T. A. ;

Shadrina, M. I. ;

Agniullin, Ya. V. ;

Shram, S. I. ;

Slominskii, P. A. ;

Limborska, S. A. ;

Myasoedov, N. F. .

DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2010, 430 (01) :5-6

[7]

Kozlovskaya MM, 2003, SOTS KLIN PSIKHIATIY, V13, P28

[8] Protective antithrombotic effects of proline-containing peptides under the influence of stress on the animal organism [J].

Lyapina, L. A. ;

Grigor'eva, M. E. ;

Andreeva, L. A. ;

Myasoedov, N. F. .

BIOLOGY BULLETIN, 2010, 37 (04) :392-396

[9]

Moussaoui N, 2017, J NEUROGASTROENTEROL, V23, P135

[10] State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment [J].

Mukhina, A. Yu. ;

Medvedeva, O. A. ;

Svishcheva, M. V. ;

Shevchenko, A. V. ;

Efremova, N. N. ;

Bobyntsev, I. I. ;

Kalutskii, P. V. ;

Andreeva, L. A. ;

Myasoedov, N. F. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2019, 167 (02) :226-228

← 1 2 →