Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

被引：48

作者：

Goto, H ^{[1
]}

Matsuo, H ^{[1
]}

Nakane, S ^{[1
]}

Izumoto, H ^{[1
]}

Fukudome, T ^{[1
]}

Kambara, C ^{[1
]}

Shibuya, N ^{[1
]}

机构：

[1] Kawatana Natl Hosp, Dept Neurol, Nagasaki 8593615, Japan

来源：

THERAPEUTIC APHERESIS | 2001年 / 5卷 / 06期

关键词：

immunomodulation; plasmapheresis; T helper type-1; T helper type-2;

D O I：

10.1046/j.1526-0968.2001.00386.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

引用

页码：494 / 496

页数：3

共 9 条

[1] FUNCTIONAL AND MOLECULAR ASPECTS OF HUMAN LYMPHOCYTE-T ACTIVATION VIA T3-TI-PATHWAYS AND T11-PATHWAYS [J].

ALCOVER, A ;

RAMARLI, D ;

RICHARDSON, NE ;

CHANG, HC ;

REINHERZ, EL .

IMMUNOLOGICAL REVIEWS, 1987, 95 :5-36

[2] THE T-CELL RECEPTOR/CD3 COMPLEX - A DYNAMIC PROTEIN ENSEMBLE [J].

CLEVERS, H ;

ALARCON, B ;

WILEMAN, T ;

TERHORST, C .

ANNUAL REVIEW OF IMMUNOLOGY, 1988, 6 :629-662

[3]

Hehmke B, 2000, Ther Apher, V4, P296, DOI 10.1046/j.1526-0968.2000.004004296.x

[4] The expanding universe of T-cell subsets: Th1, Th2 and more [J].

Mosmann, TR ;

Sad, S .

IMMUNOLOGY TODAY, 1996, 17 (03) :138-146

[5]

MOSMANN TR, 1989, ANNU REV IMMUNOL, V7, P145, DOI 10.1146/annurev.iy.07.040189.001045

[6]

ORIGUCHI T, 1991, THERAPEUTIC PLASMOPH, P517

[7]

TOMITA I, 1993, THERAPEUTIC PLASMAPH, P619

[8] Decrease in peripheral type 1 over type 2 T cell cytokine production in patients with rheumatoid arthritis correlates with an increase in severity of disease [J].

vanRoon, JAG ;

Verhoef, CM ;

vanRoy, JLAM ;

GmeligMeyling, FHJ ;

HuberBruning, O ;

Lafeber, FPJG ;

Bijlsma, JWJ .

ANNALS OF THE RHEUMATIC DISEASES, 1997, 56 (11) :656-660

[9]

VERWILGHEN J, 1993, J IMMUNOL, V150, P835

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