Microcarcinoids associated with diversion colitis in a patient with Crohn's disease

被引：3

作者：

Borralho, Paula ^{[1
]}

Vieira, Ana ^{[2
]}

Loureiro, Rui ^{[2
]}

Pereira, Pedro Moniz ^{[3
]}

de Freitas, Joao ^{[2
]}

机构：

[1] Hosp Garcia de Orta, Serv Anat Patol, P-2901851 Pragal, Almada, Portugal

[2] Garcia de Orta Hosp, Dept Gastroenterol, Almada, Portugal

[3] Garcia de Orta Hosp, Dept Surg, Almada, Portugal

来源：

JOURNAL OF CROHNS & COLITIS | 2008年 / 2卷 / 03期

关键词：

Diversion colitis; Crohn's disease; Microcarcinoids;

D O I：

10.1016/j.crohns.2008.05.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Diversion colitis is an iatrogenic disorder related to surgical diversion of the faecal stream from the colorectal mucosa, first described by Morson in 1972. Inflammation of the defunctioned mucosa seems to be related to deprivation of luminal nutrients, in particular short chain fatty acids. Histologic abnormalities include damage of the epithelium and reparative changes with crypt distortion and branching, a mixed acute and chronic inflammatory infiltrate with crypt abscesses and lymphoid hyperplasia, Paneth cell metaplasia and thickening of the muscularis mucosae. We report a case of diversion colitis in a 51-year-old female with Crohn's disease with multiple submucosal microcarcinoids in the rectal stump 17 years after diversion and discuss the hypothesis that hyperplastic and neoplastic lesions of neuroendocrine cells can result from proliferative response to chronic inflammation and repair, as well as epithelial neoplasms. (c) 2008 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

引用

页码：246 / 249

页数：4

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