Medical Management of Persistent and Recurrent Cushing Disease

被引：24

作者：

Fleseriu, Maria ^{[1
,2
]}

机构：

[1] Oregon Hlth & Sci Univ, NW Pituitary Ctr, Dept Med, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol Surg, Portland, OR 97239 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 04期

关键词：

Cushing disease; Failed transphenoidal surgery; Recurrent Cushing disease; Somatostatin receptor ligands; Pasireotide; Glucocorticoid receptor antagonist; Mifepristone; Adrenal steroidogenesis inhibitors; CORTICOTROPH PITUITARY-ADENOMAS; LONG-TERM TREATMENT; LOW-DOSE ETOMIDATE; TRANSSPHENOIDAL SURGERY; NELSONS-SYNDROME; ADRENOCORTICOTROPIN SECRETION; SOMATOSTATIN RECEPTOR-TYPE-5; CYPROHEPTADINE TREATMENT; KETOCONAZOLE TREATMENT; CONSENSUS STATEMENT;

D O I：

10.1016/j.nec.2012.06.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent evidence supports the notion that the incidence of Cushing disease is higher than previously thought. Transphenoidal surgery, in the hands of experienced neurosurgeons, is currently considered the first-line treatment of choice. However, an examination of remission and recurrence rates in long-term follow-up studies reveals that potentially up to 40% to 50% of patients could require additional treatment. If left untreated, the resultant morbidity and mortality are high. Successful clinical management of patients with Cushing disease remains a challenge. The development of new therapeutic agents has been eagerly anticipated. This article discusses the results of currently available and promising new therapeutic agents used to treat this challenging disease.

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收藏

页码：653 / +

页数：17

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