The Molecular Constituents of the Blood-Brain Barrier

被引：283

作者：

Chow, Brian Wai ^{[1
]}

Gu, Chenghua ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

TRENDS IN NEUROSCIENCES | 2015年 / 38卷 / 10期

关键词：

PROTEIN-COUPLED RECEPTOR; MDR1A P-GLYCOPROTEIN; CIRCUMVENTRICULAR ORGANS; VASCULAR DEVELOPMENT; ENDOTHELIAL-CELLS; CNS ANGIOGENESIS; TIGHT JUNCTIONS; TRANSPORT; MFSD2A; GPR124;

D O I：

10.1016/j.tins.2015.08.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier (BBB) maintains the optimal microenvironment in the central nervous system (CNS) for proper brain function. The BBB comprises specialized CNS endothelial cells with fundamental molecular properties essential for the function and integrity of the BBB. The restrictive nature of the BBB hinders the delivery of therapeutics for many neurological disorders. In addition, recent evidence shims that BBB dysfunction can precede or hasten the progression of several neurological diseases. Despite the physiological significance of the BBB in health and disease, major discoveries of the molecular regulators of BBB formation and function have occurred only recently. This review highlights recent findings describing the molecular determinants and core cellular pathways that confer BBB properties on CNS endothelial cells.

引用

页码：598 / 608

页数：11

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