Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4′,5′-d][1,3]thiazine: a combined experimental and computational study

被引：4

作者：

Afrough, Toktam ^{[1
]}

Bakavoli, Mehdi ^{[1
]}

Eshghi, Hossein ^{[1
]}

Tajabadi, Javad ^{[1
]}

Mague, Joel ^{[2
]}

机构：

[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 917751436, Razavi Khorasan, Iran

[2] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

来源：

JOURNAL OF SULFUR CHEMISTRY | 2019年 / 40卷 / 03期

关键词：

Dipyrimido[2; 1-b; 4 '; 5 '-d] [1; 3]thiazine; heterocyclization; regioselectivity; computational calculations; DERIVATIVES; STEEL;

D O I：

10.1080/17415993.2019.1576685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several derivatives of the novel tricyclic system 'dipyrimido[2,1-b:4 ',5 '-d][1,3]thiazine' were synthesized via inter- and intramolecular heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine and 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile in short reaction times under mild conditions. An x-ray analysis together with computational calculations was performed to gain an in-depth understanding of regioselectivity of the reaction. [GRAPHICS] .

引用

页码：265 / 276

页数：12

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