Antigen Delivery to Plasmacytoid Dendritic Cells - Induction of Tolerance and Immunity

被引：4

作者：

Loschko, Jakob ^{[1
]}

Krug, Anne B. ^{[2
]}

机构：

[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA

[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-81675 Munich, Germany

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 2012年 / 32卷 / 06期

关键词：

Plasmacytoid dendritic cells; antigen targeting; tolerance; immunity; C-TYPE LECTIN; IN-VIVO; T-CELLS; SIGLEC-H; RESPONSES; MOUSE; RECEPTOR; ANTIBODY; SUBSETS; CD4(+);

D O I：

10.1615/CritRevImmunol.v32.i6.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells are professional antigen presenting cells linking the innate and the adaptive immune system. Antibody mediated antigen delivery to functionally distinct DC subpopulatdons is a promising approach to induce or inhibit antigen specific immune responses in vivo and is useful for designing therapeutic vaccination strategies. This review focuses on the state of the art of this technique and describes recent findings of antigen targeting to the subpopulation of plasmacytoid dendritic cells and the possibilities to induce immunity or attenuate autoimmunity by delivering antigens specifically to this cell type.

引用

页码：489 / 501

页数：13

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