Stereoselective synthesis of NEO-C-glycopeptide building blocks: Towards a flexible and control-oriented design as probes for carbohydrate-protein interactions

被引：14
作者：
Arya, P
Dion, S
Shimizu, GKH
机构：
[1] Steacie Inst. for Molecular Sciences, National Research Council of Canada, Ottawa
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(97)00255-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Neo-C-glycopeptides (1-4) have been synthesized as building blocks to obtain higher neo-C-glycopeptides as probes for studying carbohydrate-protein interactions. A convergent approach for the synthesis of 4 has been developed, in which two galactose units are attached to a glycine derivative in a stepwise procedure (reductive amination followed by amide coupling) and finally coupling to the protected dipeptide having a free amino group on the side chain. (C) 1997 Elsevier Science Ltd.
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页码：1537 / 1542
页数：6
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