Evaluation of the neurovirulence test for mumps vaccines

被引：23

作者：

Afzal, MA ^{[1
]}

Marsden, SA ^{[1
]}

Hull, RM ^{[1
]}

Pipkin, PA ^{[1
]}

Bentley, ML ^{[1
]}

Minor, PD ^{[1
]}

机构：

[1] Natl Inst Biol Stand & Controls, Div Virol, Potters Bar EN6 3QG, Herts, England

来源：

BIOLOGICALS | 1999年 / 27卷 / 01期

关键词：

D O I：

10.1006/biol.1999.0174

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurovirulence tests in Macaca fascicularis using commercial preparations of different vaccine bulks and a wild-type strain revealed that the test was unable to distinguish mixed from pure populations or a suitable vaccine from a related strain which has been shown to be associated with clinical meningitis. However, the test was able to distinguish a wild-type strain from the vaccine strains successfully. The ability of the test to discriminate between acceptable and unacceptable seeds requires further examination. (C) 1999 The International Association for Biologicals.

引用

页码：43 / 49

页数：7

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