The Genetic Basis of Coronary Artery Disease: From Candidate Genes to Whole Genome Analysis

被引：29

作者：

Franchini, Massimo ^{[4
]}

Peyvandi, Flora ^{[1
,2
,3
]}

Mannucci, Pier Mannuccio ^{[1
,2
,3
]}

机构：

[1] Univ Milan, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, I-20122 Milan, Italy

[2] Univ Milan, Dept Med & Med Specialties, Luigi Villa Fdn, I-20122 Milan, Italy

[3] Maggiore Hosp, IRCCS, Mangiagalli & Regina Elena Fdn, Milan, Italy

[4] Univ Hosp Parma, Immunohematol & Transfus Ctr, Parma, Italy

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2008年 / 18卷 / 05期

关键词：

D O I：

10.1016/j.tcm.2008.04.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary artery disease is a major socioeconomic problem in industrialized as well as in developing countries. Thus, many research efforts continue to address the identification of acquired and inherited risk factors of this complex disease. Recent advances in genotyping technology have made available newer and more powerful tools I-or the identification of susceptibility genes that in turn may provide new opportunities to evaluate the individual cardiovascular risk profile, detect novel disease pathways, and develop innovative therapeutic approaches. Replication of results is essential to establish unequivocally the impact of genetic variants in complex diseases. At the moment, only distinct but tightly linked single nucleotide polymorphisms on chromosome 9 have been consistently shown to be associated with different clinical phenotypes of coronary artery disease. (Trends Cardiovasc Med 2 008; IS: 157-162) (C) 2008, Elsevier Inc.

引用

页码：157 / 162

页数：6

共 51 条

[21] Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes [J].

Larson, Martin G. ;

Atwood, Larry D. ;

Benjamin, Emelia J. ;

Cupples, L. Adrienne ;

D'Agostino, Ralph B., Sr. ;

Fox, Caroline S. ;

Govindaraju, Diddahally R. ;

Guo, Chao-Yu ;

Heard-Costa, Nancy L. ;

Hwang, Shih-Jen ;

Murabito, Joanne M. ;

Newton-Cheh, Christopher ;

O'Donnell, Christopher J. ;

Seshadri, Sudha ;

Vasan, Ramachandran S. ;

Wang, Thomas J. ;

Wolf, Philip A. ;

Levy, Daniel .

BMC MEDICAL GENETICS, 2007, 8

[22] A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease [J].

Luke, May M. ;

Kane, John P. ;

Liu, Dongming M. ;

Rowland, Charles M. ;

Shiffman, Dov ;

Cassano, June ;

Catanese, Joseph J. ;

Pullinger, Clive R. ;

Leong, Diane U. ;

Arellano, Andre R. ;

Tong, Carmen H. ;

Movsesyan, Irina ;

Naya-Vigne, Josephina ;

Noordhof, Curtis ;

Feric, Nicole T. ;

Malloy, Mary J. ;

Topol, Eric J. ;

Koschinsky, Marlys L. ;

Devlin, James J. ;

Ellis, Stephen G. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (09) :2030-2036

[23] No evidence of association between prothrombotic gene Polymorphisms and the development of acute myocardial infarction at a young age [J].

Mannucci, PM ;

Merlini, PA ;

Ardissino, D ;

Barzuini, C ;

Bernardi, F ;

Bernardinelli, L ;

Cavallini, C ;

Celli, P ;

Corsini, G ;

Ferrario, M ;

Fetiveau, R ;

Galli, M ;

Peyvandi, F ;

Piazza, A ;

Ribichini, F ;

Sacchi, E ;

Tubaro, M ;

Zonzin, P ;

Bernardinelli, L ;

Berzuini, C ;

Foco, L ;

Tagliabue, L ;

Menegatti, M ;

Peyvandi, F ;

Sacchi, E ;

Repetto, A ;

Canosi, U ;

Cucci, V ;

Buratti, S ;

Tubaro, M ;

Ferrario, M ;

Ponzetta, M ;

Fetiveau, R ;

Rinuncini, M ;

Spolverato, M ;

Vetrano, A ;

Lamponi, M ;

Cacciavillani, L ;

Russo, G ;

Colizzi, A ;

Pagnoni, N ;

Colombi, E ;

Covini, D ;

Fantini, G ;

Dodi, C ;

Paoloni, P ;

Moaddi, I ;

Bardelli, G ;

Azzarito, M ;

Beciani, M .

CIRCULATION, 2003, 107 (08) :1117-1122

[24] Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes [J].

McCarthy, JJ ;

Parker, A ;

Salem, R ;

Moliterno, DJ ;

Wang, Q ;

Plow, EF ;

Rao, S ;

Shen, G ;

Rogers, WJ ;

Newby, LK ;

Cannata, R ;

Glatt, K ;

Topol, EJ .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (05) :334-341

[25] A common allele on chromosome 9 associated with coronary heart disease [J].

McPherson, Ruth ;

Pertsemlidis, Alexander ;

Kavaslar, Nihan ;

Stewart, Alexandre F. R. ;

Roberts, Robert ;

Cox, David R. ;

Hinds, David A. ;

Pennacchio, Len A. ;

Tybjaerg-Hansen, Anne ;

Folsom, Aaron R. ;

Boerwinkle, Eric ;

Hobbs, Helen H. ;

Cohen, Jonathan C. .

SCIENCE, 2007, 316 (5830) :1488-1491

[26] Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study [J].

Morgan, Thomas M. ;

Krumholz, Harlan M. ;

Lifton, Richard P. ;

Spertus, John A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (14) :1551-1561

[27] Coronary artery disease in the developing world [J].

Okrainec, K ;

Banerjee, DK ;

Eisenberg, MJ .

AMERICAN HEART JOURNAL, 2004, 148 (01) :7-15

[28] Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro [J].

Ozaki, K ;

Inoue, K ;

Sato, H ;

Iida, A ;

Ohnishi, Y ;

Sekine, A ;

Sato, H ;

Odashiro, K ;

Nobuyoshi, M ;

Hori, M ;

Nakamura, Y ;

Tanaka, T .

NATURE, 2004, 429 (6987) :72-75

[29] Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction [J].

Ozaki, K ;

Ohnishi, Y ;

Iida, A ;

Sekine, A ;

Yamada, R ;

Tsunoda, T ;

Sato, H ;

Hori, M ;

Nakamura, Y ;

Tanaka, T .

NATURE GENETICS, 2002, 32 (04) :650-654

[30] Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland [J].

Pajukanta, P ;

Cargill, M ;

Viitanen, L ;

Nuotio, I ;

Kareinen, A ;

Perola, M ;

Terwilliger, JD ;

Kempas, E ;

Day, M ;

Lilja, H ;

Rioux, JD ;

Brettin, T ;

Viikari, JSA ;

Rönnemaa, T ;

Laakso, M ;

Lander, ES ;

Peltonen, L .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (06) :1481-1493

← 1 2 3 4 5 6 →