The Genetic Basis of Coronary Artery Disease: From Candidate Genes to Whole Genome Analysis

被引：29
作者：
Franchini, Massimo [4 ]
Peyvandi, Flora [1 ,2 ,3 ]
Mannucci, Pier Mannuccio [1 ,2 ,3 ]
机构：
[1] Univ Milan, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, I-20122 Milan, Italy
[2] Univ Milan, Dept Med & Med Specialties, Luigi Villa Fdn, I-20122 Milan, Italy
[3] Maggiore Hosp, IRCCS, Mangiagalli & Regina Elena Fdn, Milan, Italy
[4] Univ Hosp Parma, Immunohematol & Transfus Ctr, Parma, Italy
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2008年 / 18卷 / 05期
关键词：
D O I：
10.1016/j.tcm.2008.04.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronary artery disease is a major socioeconomic problem in industrialized as well as in developing countries. Thus, many research efforts continue to address the identification of acquired and inherited risk factors of this complex disease. Recent advances in genotyping technology have made available newer and more powerful tools I-or the identification of susceptibility genes that in turn may provide new opportunities to evaluate the individual cardiovascular risk profile, detect novel disease pathways, and develop innovative therapeutic approaches. Replication of results is essential to establish unequivocally the impact of genetic variants in complex diseases. At the moment, only distinct but tightly linked single nucleotide polymorphisms on chromosome 9 have been consistently shown to be associated with different clinical phenotypes of coronary artery disease. (Trends Cardiovasc Med 2 008; IS: 157-162) (C) 2008, Elsevier Inc.
引用
收藏
页码：157 / 162
页数：6
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