Current metabolomics: Technological advances

被引：144
作者：
Putri, Sastia P. [1 ]
Yamamoto, Shinya [1 ]
Tsugawa, Hiroshi [1 ]
Fukusaki, Eiichiro [1 ]
机构：
[1] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2013年 / 116卷 / 01期
基金：
日本学术振兴会;
关键词：
Metabolomics; Metabolome; Mass spectrometry; Chemometrics; Multivariate analysis; MASS-SPECTROMETRY DATA; PERFORMANCE LIQUID-CHROMATOGRAPHY; HIGH-THROUGHPUT; METABOLITE IDENTIFICATION; ELECTROSPRAY INTERFACE; QUANTITATIVE-ANALYSIS; ANIONIC METABOLITES; ENRICHMENT ANALYSIS; GAS-CHROMATOGRAPHY; FLOW-INJECTION;
D O I：
10.1016/j.jbiosc.2013.01.004
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Metabolomics, the global quantitative assessment of metabolites in a biological system, has played a pivotal role in various fields of science in the post-genomic era. Metabolites are the result of the interaction of the system's genome with its environment and are not merely the end product of gene expression, but also form part of the regulatory system in an integrated manner. Therefore, metabolomics is often considered a powerful tool to provide an instantaneous snapshot of the physiology of a cell. The power of metabolotnics lies on the acquisition of analytical data in which metabolites in a cellular system are quantified, and the extraction of the most meaningful elements of the data by using various data analysis tool. In this review, we discuss the latest development of analytical techniques and data analyses methods in metabolomics study. (C) 2013, The Society for Biotechnology, Japan. All rights reserved.
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收藏
页码：9 / 16
页数：8
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