Blood Eosinophil Counts in Clinical Trials for Chronic Obstructive Pulmonary Disease

被引：76

作者：

Singh, Dave ^{[1
]}

Bafadhel, Mona ^{[2
]}

Brightling, Christopher E. ^{[3
]}

Sciurba, Frank C. ^{[4
]}

Curtis, Jeffrey L. ^{[5
,6
]}

Martinez, Fernando J. ^{[7
]}

Pasquale, Cara B. ^{[8
]}

Merrill, Debora D. ^{[9
]}

Metzdorf, Norbert ^{[10
]}

Petruzzelli, Stefano ^{[11
]}

Tal-Singer, Ruth ^{[9
]}

Compton, Christopher ^{[12
]}

Rennard, Stephen ^{[13
,14
]}

Martin, Ubaldo J. ^{[15
]}

机构：

[1] Univ Manchester, Manchester Univ Natl Hlth Serv Hosp Trust, Div Infect Immun & Resp Med, Southmoor Rd, Manchester M23 9QZ, Lancs, England

[2] Univ Oxford, Nuffield Dept Med, Resp Med Unit, Oxford, England

[3] Univ Leicester, Natl Inst Hlth Res Leicester Biomed Res Ctr, Inst Lung Hlth, Dept Resp & Infect Sci, Leicester, Leics, England

[4] Univ Pittsburgh, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

[5] VA Ann Arbor Healthcare Syst, Pulm & Crit Care Med, Ann Arbor, MI USA

[6] Univ Michigan, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

[7] Weill Cornell Med Coll, Pulm & Crit Care Med, New York, NY USA

[8] COPD Fdn, COPD Patient Powered Res Network, Washington, DC USA

[9] COPD Fdn, COPD Biomarkers Qualificat Consortium, Miami, FL USA

[10] Boehringer Ingelheim Int GmbH, Ingelheim, Germany

[11] Chiesi Farmaceut, Global Clin Dev, Parma, Italy

[12] GlaxoSmithKline, Global Med Affairs Special & Primary Care, Brentford, Middx, England

[13] AstraZeneca, Biopharmaceut R&D, Cambridge, England

[14] Univ Nebraska Med Ctr, Omaha, NE USA

[15] AstraZeneca, Res & Dev, Gaithersburg, MD USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2020年 / 202卷 / 05期

关键词：

INHALED FLUTICASONE FUROATE; SHORT-TERM RESPONSE; POST-HOC ANALYSIS; SPUTUM-EOSINOPHILIA; EXTRAFINE BECLOMETHASONE/FORMOTEROL; EXACERBATION RISK; CIGARETTE-SMOKING; PARALLEL-GROUP; DOUBLE-BLIND; COPD;

D O I：

10.1164/rccm.201912-2384PP

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

[No abstract available]

引用

页码：660 / 671

页数：12

共 80 条

[1] Treatable traits: toward precision medicine of chronic airway diseases [J].

Agusti, Alvar ;

Bel, Elisabeth ;

Thomas, Mike ;

Vogelmeier, Claus ;

Brusselle, Guy ;

Holgate, Stephen ;

Humbert, Marc ;

Jones, Paul ;

Gibson, Peter G. ;

Vestbo, Jorgen ;

Beasley, Richard ;

Pavord, Ian D. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) :410-419

[2] Eosinophils and Disease Pathogenesis [J].

Akuthota, Praveen ;

Weller, Peter F. .

SEMINARS IN HEMATOLOGY, 2012, 49 (02) :113-119

[3] Prognostic utility of biochemical markers of cardiovascular risk: impact of biological variability [J].

Alexander, Kristine S. ;

Kazmierczak, Steven C. ;

Snyder, Caryn K. ;

Oberdorf, Jon A. ;

Farrell, David H. .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2013, 51 (09) :1875-1882

[4] Inhaled Steroids, Circulating Eosinophils, Chronic Airway Infection, and Pneumonia Risk in Chronic Obstructive Pulmonary Disease A Network Analysis [J].

Angel Martinez-Garcia, Miguel ;

Faner, Rosa ;

Oscullo, Grace ;

de la Rosa, David ;

Soler-Cataluna, Juan-Jose ;

Ballester, Marta ;

Agusti, Alvar .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201 (09) :1078-1085

[5]

[Anonymous], 2016, BEST (Biomarkers, EndpointS, and other Tools) Resource

[6]

Arneth B., 2016, J HEMATOL BROSSARD, V5, P49, DOI DOI 10.14740/JH265W

[7] Sputum IL-5 Concentration Is Associated with a Sputum Eosinophilia and Attenuated by Corticosteroid Therapy in COPD [J].

Bafadhel, M. ;

Saha, S. ;

Siva, R. ;

McCormick, M. ;

Monteiro, W. ;

Rugman, P. ;

Dodson, P. ;

Pavord, I. D. ;

Newbold, P. ;

Brightling, C. E. .

RESPIRATION, 2009, 78 (03) :256-262

[8]

Bafadhel M, 2019, EUR RESPIR J, V52

[9]

BAFADHEL M, 2009, AM J RESP CRIT CARE, V179

[10] Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials [J].

Bafadhel, Mona ;

Peterson, Stefan ;

De Blas, Miguel A. ;

Calverley, Peter M. ;

Rennard, Stephen I. ;

Richter, Kai ;

Fageras, Malin .

LANCET RESPIRATORY MEDICINE, 2018, 6 (02) :117-126

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