Should antidepressant drugs of the selective serotonin reuptake inhibitor family be tested as antiepileptic drugs?

被引：48

作者：

Hamid, Hamada ^{[1
]}

Kanner, Andres M. ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06520 USA

[2] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA

来源：

EPILEPSY & BEHAVIOR | 2013年 / 26卷 / 03期

关键词：

Temporal lobe epilepsy; Raphe nuclei; Intractable epilepsy; Genetically epilepsy-prone rats; 5-HT1A RECEPTOR-BINDING; SOUND-INDUCED SEIZURES; EXTRACELLULAR SEROTONIN; PHARMACODYNAMIC MARKERS; ANTICONVULSANT ACTION; HIPPOCAMPAL DOPAMINE; EPILEPTIC SEIZURES; LATERAL HABENULA; 5-HYDROXYTRYPTAMINE; DEPRESSION;

D O I：

10.1016/j.yebeh.2012.10.009

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

For a long time, there has been a misconception that all antidepressant drugs have proconvulsant effects. Yet, antidepressants of the selective serotonin reuptake inhibitor (SSRI) family not only have been shown to be safe when used in patients with epilepsy (PWE) but also have been found to possess antiepileptic properties in animal models of epilepsy. In humans randomized to SSRIs vs. placebo for the treatment of major depressive episodes, the incidence of epileptic seizures was significantly lower among those treated with the antidepressants. These data raise the question of whether there is enough evidence that would support a randomized placebo-controlled trial to test antiepileptic effect of SSRIs in PWE. This article reviews the preclinical and clinical data to address this question. This article is part of a Special Issue entitled "The Future of Translational Epilepsy Research". (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：261 / 265

页数：5

共 62 条

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