Synthesis and Characterization of Hyaluronic Acid Modified Colloidal Mesoporous Silica Nanoparticles

被引：3
作者：
Zhang, Wenbiao [1 ,2 ,3 ]
Wang, Yu [1 ,2 ,3 ]
Li, Zhen [1 ,2 ,3 ]
Wang, Wanxia [1 ,2 ,3 ]
Sun, Honghao [1 ,2 ,3 ]
Liu, Mingxing [1 ,2 ,3 ]
机构：
[1] Hubei Univ Technol, Minist Educ, Key Lab Fermentat Engn, Wuhan 430068, Hubei, Peoples R China
[2] Hubei Univ Technol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Wuhan 430068, Hubei, Peoples R China
[3] Hubei Univ Technol, Hubei Key Lab Ind Microbiol, Wuhan 430068, Hubei, Peoples R China
来源：
5TH ANNUAL INTERNATIONAL CONFERENCE ON MATERIAL SCIENCE AND ENGINEERING (ICMSE2017) | 2018年 / 275卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1088/1757-899X/275/1/012009
中图分类号：
TH [机械、仪表工业];
学科分类号：
0802 ;
摘要：
The colloidal mesoporous silica nanoparticles functionalized with hyaluronic acid (CMS-HA) were successfully synthesized by grafting hyaluronic acid onto the external surface of the amino-functionalized mesoporous silica nanoparticles (CMS-NH2). Moreover, the paticle properties of CMS-HA were characterized by fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The nanomaterials were negatively charged and had a relatively uniform spherical morphology with about 100 nm in diameter, which could make it more compatible with blood. So the results suggested that the CMS-HA might be a critical nanomaterial for applying in target drug delivery system.
引用
收藏
页数：4
相关论文
共 11 条
[1]   Impact of different PEGylation patterns on the long-term bio-stability of colloidal mesoporous silica nanoparticles [J].
Cauda, Valentina ;
Argyo, Christian ;
Bein, Thomas .
JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (39) :8693-8699
[2]   Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution [J].
Choi, Ki Young ;
Min, Kyung Hyun ;
Na, Jin Hee ;
Choi, Kuiwon ;
Kim, Kwangmeyung ;
Park, Jae Hyung ;
Kwon, Ick Chan ;
Jeong, Seo Young .
JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (24) :4102-4107
[3]   Heparanase, hyaluronan, and CD44 in cancers:: A breast carcinoma perspective [J].
Gotte, Martin ;
Yip, George W. .
CANCER RESEARCH, 2006, 66 (21) :10233-10237
[4]   Colloidal suspensions of functionalized mesoporous silica nanoparticles [J].
Kobler, Johannes ;
Moeller, Karin ;
Bein, Thomas .
ACS NANO, 2008, 2 (04) :791-799
[5]   Hyaluronic acid-conjugated mesoporous silica nanoparticles: excellent colloidal dispersity in physiological fluids and targeting efficacy [J].
Ma, Ming ;
Chen, Hangrong ;
Chen, Yu ;
Zhang, Kun ;
Wang, Xia ;
Cui, Xiangzhi ;
Shi, Jianlin .
JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (12) :5615-5621
[6]   Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine [J].
Prestwich, Glenn D. .
JOURNAL OF CONTROLLED RELEASE, 2011, 155 (02) :193-199
[7]   Multifunctional Tumor-Targeting Nanocarriers Based on Hyaluronic Acid-Mediated and pH-Sensitive Properties for Efficient Delivery of Docetaxel [J].
Song, Shuangshuang ;
Chen, Fen ;
Qi, Huan ;
Li, Fei ;
Xin, Tiegang ;
Xu, Jingwen ;
Ye, Tiantian ;
Sheng, Naicheng ;
Yang, Xinggang ;
Pan, Weisan .
PHARMACEUTICAL RESEARCH, 2014, 31 (04) :1032-1045
[8]   Colloidal Mesoporous Silica Nanoparticles [J].
Yamamoto, Eisuke ;
Kuroda, Kazuyuki .
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2016, 89 (05) :501-539
[9]   Reversing Cancer Multidrug Resistance in Xenograft Models via Orchestrating Multiple Actions of Functional Mesoporous Silica Nanoparticles [J].
Yang, Debin ;
Wang, Tingfang ;
Su, Zhigui ;
Xue, Lingjing ;
Mo, Ran ;
Zhang, Can .
ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (34) :22431-22441
[10]   Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells [J].
Yu, Meihua ;
Jambhrunkar, Siddharth ;
Thorn, Peter ;
Chen, Jiezhong ;
Gu, Wenyi ;
Yu, Chengzhong .
NANOSCALE, 2013, 5 (01) :178-183
12