More about Imatinib and Nilotinib Combination Therapy in Chronic Myeloid Leukemia

被引:4
作者
Gomez-Almaguer, David [1 ]
Tarin-Arzaga, Luz [1 ]
Cantu-Rodriguez, Olga [1 ]
Ceballos-Lopez, Adrian [1 ]
机构
[1] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose E Gonzalez, Div Internal Med, Hematol Serv,Colonia Mitras Ctr, Monterrey, Mexico
关键词
COMBINING NILOTINIB;
D O I
10.1159/000342455
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:18 / 19
页数:2
相关论文
共 5 条
[1]   Comparison of imatinib, mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen:: high efficacy of drug combinations [J].
Bradeen, Heather A. ;
Eide, Christopher A. ;
O'Hare, Thomas ;
Johnson, Kara J. ;
Willis, Stephanie G. ;
Lee, Francis Y. ;
Druker, Brian J. ;
Deininger, Michael W. .
BLOOD, 2006, 108 (07) :2332-2338
[2]   A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal Stromal Tumors [J].
Demetri, George D. ;
Casali, Paolo G. ;
Blay, Jean-Yves ;
von Mehren, Margaret ;
Morgan, Jeffrey A. ;
Bertulli, Rossella ;
Ray-Coquard, Isabelle ;
Cassier, Philippe ;
Davey, Monica ;
Borghaei, Hossein ;
Pink, Daniel ;
Debiec-Rychter, Maria ;
Cheung, Wing ;
Bailey, Stuart M. ;
Veronese, Maria Luisa ;
Reichardt, Annette ;
Fumagalli, Elena ;
Reichardt, Peter .
CLINICAL CANCER RESEARCH, 2009, 15 (18) :5910-5916
[3]   Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias [J].
Weisberg, Ellen ;
Catley, Laurie ;
Wright, Renee D. ;
Moreno, Daisy ;
Banerji, Lolita ;
Ray, Arghya ;
Manley, Paul W. ;
Mestan, Juergen ;
Fabbro, Doriano ;
Jiang, Jingrui ;
Hall-Meyers, Elizabeth ;
Callahan, Linda ;
DellaGatta, Jamie L. ;
Kung, Andrew L. ;
Griffin, James D. .
BLOOD, 2007, 109 (05) :2112-2120
[4]   Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs [J].
White, Deborah L. ;
Saunders, Verity A. ;
Quinn, Steven R. ;
Manley, Paul W. ;
Hughes, Timothy P. .
BLOOD, 2007, 109 (08) :3609-3610
[5]   Combining Nilotinib and Imatinib Improves the Outcome of Imatinib-Resistant Blast Phase CML [J].
Zhu, Guang-rong ;
Ji, Ou ;
Ji, Jian-min ;
Zhang, Ya-cheng ;
Wu, Yu ;
Yu, Hui ;
Jiang, Peng-Jun ;
Shen, Qun .
ACTA HAEMATOLOGICA, 2012, 127 (03) :152-155